Mephyton Side Effects
Generic Name: phytonadione
Note: This page contains information about the side effects of phytonadione. Some of the dosage forms included on this document may not apply to the brand name Mephyton.
For the Consumer
Applies to phytonadione: capsule, tablet
In addition to its needed effects, some unwanted effects may be caused by phytonadione (the active ingredient contained in Mephyton). In the event that any of these side effects do occur, they may require medical attention.
Severity: Moderate
If any of the following side effects occur while taking phytonadione, check with your doctor or nurse as soon as possible:
Less common: - With menadiol or high doses of phytonadione in newborns- Decreased appetite
- decreased movement or activity
- difficulty in breathing
- enlarged liver
- general body swelling
- irritability
- muscle stiffness
- paleness
- yellow eyes or skin
- Difficulty in swallowing
- fast or irregular breathing
- lightheadedness or fainting
- shortness of breath
- skin rash, hives and/or itching
- swelling of eyelids, face, or lips
- tightness in chest
- troubled breathing and/or wheezing
- Blue color or flushing or redness of skin
- dizziness
- fast and/or weak heartbeat
- increased sweating
- low blood pressure (temporary)
Minor Side Effects
Some of the side effects that can occur with phytonadione may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
Less common:- Flushing of face
- redness, pain, or swelling at place of injection
- skin lesions at place of injection (rare)
- unusual taste
For Healthcare Professionals
Applies to phytonadione: compounding powder, injectable solution, oral tablet
Local
Rare (less than 0.1%): Injection site reactions (inflammation, atrophy, necrosis)
Very rare (less than 0.01%): Venous irritation or phlebitis (IV route)
Frequency not reported: Pain, swelling, and tenderness at the injection site[Ref]
Cardiovascular
Rare (less than 0.1%): Rapid and weak pulse, brief hypotension, cyanosis
Very rare (less than 0.01%): Facial flushing[Ref]
Hypersensitivity
Very rare (less than 0.01%): Anaphylactoid reactions (IV route)
Frequency not reported: Allergic sensitivity, anaphylaxis[Ref]
Fatalities and other severe reactions have occurred during or immediately after the parenteral administration of phytonadione. The majority of these reactions have occurred with intravenous administration. These reactions resemble hypersensitivity or anaphylaxis and include shock and cardiac or respiratory arrest. Feelings of uneasiness, flushing, diaphoresis, chest pain, tachycardia, cyanosis, weakness, and dyspnea may precede the cardiopulmonary event. These severe reactions are more likely with, but are not limited to, rapid infusions of undiluted drug.[Ref]
Gastrointestinal
Gastrointestinal side effects have rarely included 'peculiar' sensations of taste.
Respiratory
Rare (less than 0.1%): Dyspnea[Ref]
Other
Frequency not reported: Death (IV and IM routes)[Ref]
Dermatologic
Uncommon (0.1% to 1%): Erythematous, indurated, pruritic plaques
Rare (less than 0.1%): Profuse sweating, scleroderma-like lesions,
Very rare (less than 0.01%): Sweating
Frequency not reported: Erythema perstans-like lesions[Ref]
Nervous system
Rare (less than 0.1%): Dizziness
Very rare (less than 0.01%): Unusual taste[Ref]
Hepatic
Hyperbilirubinemia occurred primarily with doses above those recommended.[Ref]
Rare (less than 0.1%): Hyperbilirubinemia in newborns
Frequency not reported: Jaundice in newborns[Ref]
Hematologic
Frequency not reported: Hemolysis in newborns[Ref]
General
The most common adverse events were dermatologic and injection site reactions.[Ref]
References
1. Cerner Multum, Inc. "Australian Product Information." O 0
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. "Product Information. Vitamin K Injection (phytonadione)." Abbott Pharmaceutical, Abbott Park, IL.
4. "Product Information. Mephyton (phytonadione)." Merck & Co, Inc, West Point, PA.
Not all side effects for Mephyton may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
More about Mephyton (phytonadione)
Consumer resources
- Other brands: Vitamin K
Professional resources
Related treatment guides
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