Luveris Side Effects

Generic name: lutropin alfa

Medically reviewed by Drugs.com. Last updated on Sep 30, 2023.

Note: This document provides detailed information about Luveris Side Effects associated with lutropin alfa. Some dosage forms listed on this page may not apply specifically to the brand name Luveris.

Applies to lutropin alfa: subcutaneous powder for solution.

Serious side effects of Luveris

Along with its needed effects, lutropin alfa (the active ingredient contained in Luveris) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking lutropin alfa:

More common side effects

• bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• bloating
• diarrhea
• stomach or pelvic discomfort, aching, or heaviness

Incidence not known (Observed after pregnancy)

• congenital abnormalities
• ectopic pregnancy
• postpartum fever
• premature labor
• spontaneous abortion

Incidence not known (Observed during menotropin therapy)

• adnexal torsion as a complication of ovarian enlargement
• blood in the peritoneal cavity
• changes in skin color
• cold hands and feet
• ovarian enlargement (mild to moderate)
• pain, redness, or swelling in the arm or leg
• troubled breathing

Get emergency help immediately if any of the following symptoms of overdose occur while taking lutropin alfa:

Symptoms of overdose

• abdominal or stomach pain
• bloating
• multiple gestation
• rapid weight gain
• severe nausea
• vomiting

Other side effects of Luveris

Some side effects of lutropin alfa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• bloated or full feeling
• breast pain
• excess air or gas in the stomach or intestines
• headache
• pain
• passing gas
• unusual tiredness or weakness

Less common side effects

• body aches or pain
• chills
• cough
• cramps
• difficulty having a bowel movement (stool)
• difficulty with breathing
• ear congestion
• fever
• heavy bleeding
• loss of voice
• nasal congestion
• ovarian disorder
• pain
• runny nose
• sneezing
• sore throat

For healthcare professionals

Applies to lutropin alfa: subcutaneous powder for injection.

General adverse events

The most commonly reported adverse events reported have included headache, pelvic and abdominal pain, nausea, injection site reactions, and mild or moderate ovarian hyperstimulation syndrome (OHSS).^[Ref]

Endocrine

• Common (1% to 10%): Ovarian hyper-stimulation syndrome (OHSS), ovarian cyst, breast pain, pelvic pain
• Frequency not reported: Abortion, breast enlargement, endometrial disorder, genital edema, hemorrhage in pregnancy, leucorrhoea, pelvic pain, pelvic congestion, ectopic pregnancy, premenstrual tension, uterine disorder not otherwise specified, uterine spasm, vaginal candidiasis, vaginal hemorrhage, vaginitis

Local

• Common (1% to 10%): Injection site reactions^[Ref]

During clinical trials, 7.4% of patients reported mild and moderate injection site reactions consisting of bruising, pain, redness, itching, or swelling; there were no reports of severe injection site reactions^[Ref]

Genitourinary

• Common (1% to 10%): Dysmenorrhea
• Frequency not reported: Dysuria, micturition frequency change^[Ref]

Gastrointestinal

• Common (1% to 10%): Abdominal pain, abdominal discomfort, nausea, vomiting, diarrhea, flatulence, constipation,
• Frequency not reported: Tooth caries^[Ref]

Cardiovascular

• Very rare (less than 0.01%): Thromboembolism
• Frequency not reported: Vasodilation^[Ref]

Musculoskeletal

• Frequency not reported: Asthenia, back pain, leg cramps, leg pain, skeletal pain^[Ref]

Nervous system

• Common (1% to 10%): Headache
• Frequency not reported: Hyperkinesia, dizziness^[Ref]

Respiratory

• Frequency not reported: Cough, dyspnea, pharyngitis, rhinitis^[Ref]

Hypersensitivity

• Very rare (less than 0.01%): Hypersensitivity reactions

Mild to severe hypersensitivity reactions including anaphylactic reactions and shock have been reported.

Immunologic

• Frequency not reported: Herpes simplex, infection, influenza-like symptoms, Klebsiella

Ocular

• Frequency not reported: Conjunctivitis

Psychiatric

• Frequency not reported: Anxiety, depression, insomnia, nervousness, somnolence

Oncologic

• Frequency not reported: Neoplasms

There have been reports of ovarian and other reproductive system neoplasms, both benign and malignant, in women who have undergone multiple treatment regimens for infertility. It has not been established whether or not treatment with gonadotropins increases the risk of these tumors in infertile women.

Other

• Frequency not reported: Fever, not otherwise specified; fever

Dermatologic

• Frequency not reported: Acne, nail disorder, rash dry skin

Further information

Luveris side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer