Luveris Side Effects

Generic name: lutropin alfa

Medically reviewed by Drugs.com. Last updated on Sep 30, 2023.

Note: This document contains side effect information about lutropin alfa. Some dosage forms listed on this page may not apply to the brand name Luveris.

Applies to lutropin alfa: subcutaneous powder for solution.

Serious side effects of Luveris

Along with its needed effects, lutropin alfa (the active ingredient contained in Luveris) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking lutropin alfa:

More common

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• bloating
• diarrhea
• stomach or pelvic discomfort, aching, or heaviness

Incidence not known (Observed after pregnancy)

• Congenital abnormalities
• ectopic pregnancy
• postpartum fever
• premature labor
• spontaneous abortion

Incidence not known (Observed during menotropin therapy)

• Adnexal torsion as a complication of ovarian enlargement
• blood in the peritoneal cavity
• changes in skin color
• cold hands and feet
• ovarian enlargement (mild to moderate)
• pain, redness, or swelling in the arm or leg
• troubled breathing

Get emergency help immediately if any of the following symptoms of overdose occur while taking lutropin alfa:

Symptoms of overdose

• Abdominal or stomach pain
• bloating
• multiple gestation
• rapid weight gain
• severe nausea
• vomiting

Other side effects of Luveris

Some side effects of lutropin alfa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Bloated or full feeling
• breast pain
• excess air or gas in the stomach or intestines
• headache
• pain
• passing gas
• unusual tiredness or weakness

Less common

• Body aches or pain
• chills
• cough
• cramps
• difficulty having a bowel movement (stool)
• difficulty with breathing
• ear congestion
• fever
• heavy bleeding
• loss of voice
• nasal congestion
• ovarian disorder
• pain
• runny nose
• sneezing
• sore throat

For Healthcare Professionals

Applies to lutropin alfa: subcutaneous powder for injection.

General

The most commonly reported adverse events reported have included headache, pelvic and abdominal pain, nausea, injection site reactions, and mild or moderate ovarian hyperstimulation syndrome (OHSS).^[Ref]

Endocrine

Common (1% to 10%): Ovarian hyper-stimulation syndrome (OHSS), ovarian cyst, breast pain, pelvic pain

Frequency not reported: Abortion, breast enlargement, endometrial disorder, genital edema, hemorrhage in pregnancy, leucorrhoea, pelvic pain, pelvic congestion, ectopic pregnancy, premenstrual tension, uterine disorder not otherwise specified, uterine spasm, vaginal candidiasis, vaginal hemorrhage, vaginitis

Local

During clinical trials, 7.4% of patients reported mild and moderate injection site reactions consisting of bruising, pain, redness, itching, or swelling; there were no reports of severe injection site reactions^[Ref]

Common (1% to 10%): Injection site reactions^[Ref]

Genitourinary

Common (1% to 10%): Dysmenorrhea

Frequency not reported: Dysuria, micturition frequency change^[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain, abdominal discomfort, nausea, vomiting, diarrhea, flatulence, constipation,

Frequency not reported: Tooth caries^[Ref]

Cardiovascular

Very rare (less than 0.01%): Thromboembolism

Frequency not reported: Vasodilation^[Ref]

Musculoskeletal

Frequency not reported: Asthenia, back pain, leg cramps, leg pain, skeletal pain^[Ref]

Nervous system

Common (1% to 10%): Headache

Frequency not reported: Hyperkinesia, dizziness^[Ref]

Respiratory

Frequency not reported: Cough, dyspnea, pharyngitis, rhinitis^[Ref]

Hypersensitivity

Very rare (less than 0.01%): Hypersensitivity reactions

Mild to severe hypersensitivity reactions including anaphylactic reactions and shock have been reported.

Immunologic

Frequency not reported: Herpes simplex, infection, influenza-like symptoms, Klebsiella

Ocular

Frequency not reported: Conjunctivitis

Psychiatric

Frequency not reported: Anxiety, depression, insomnia, nervousness, somnolence

Oncologic

Frequency not reported: Neoplasms

There have been reports of ovarian and other reproductive system neoplasms, both benign and malignant, in women who have undergone multiple treatment regimens for infertility. It has not been established whether or not treatment with gonadotropins increases the risk of these tumors in infertile women.

Other

Frequency not reported: Fever, not otherwise specified; fever

Dermatologic

Frequency not reported: Acne, nail disorder, rash dry skin

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer