Hyzine Side Effects

Generic name: hydroxyzine

Medically reviewed by Drugs.com. Last updated on Sep 4, 2023.

Note: This document provides detailed information about Hyzine.

For healthcare professionals

Applies to hydroxyzine: compounding powder, intramuscular solution, oral capsule, oral suspension, oral syrup, oral tablet Side Effects associated with hydroxyzine. Some dosage forms listed on this page may not apply specifically to the brand name Hyzine.

For healthcare professionals

Applies to hydroxyzine: compounding powder, intramuscular solution, oral capsule, oral suspension, oral syrup, oral tablet.

General

The most commonly reported side effects included sleepiness, headache, and tiredness.^[Ref]

Nervous system

• Very common (10% or more): Sleepiness (up to 13.74%)
• Common (1% to 10%): Headache
• Rare (0.01% to 0.1%): Convulsion, tremor
• Frequency not reported: Anticholinergic activity, central nervous system (CNS) depression, drowsiness, incoordination, involuntary motor activity, psychomotor impairment, stimulation
• Postmarketing reports: Dizziness, dyskinesia, dystonia, paresthesia, sedation, seizures, syncope^[Ref]

Other

• Common (1% to 10%): Tiredness
• Frequency not reported: Antimuscarinic effects, lassitude
• Postmarketing reports: Asthenia, malaise, pyrexia, sudden death^[Ref]

Gastrointestinal

• Common (1% to 10%): Dry mouth
• Postmarketing reports: Constipation, diarrhea, nausea, vomiting^[Ref]

Cardiovascular

• Frequency not reported: QT prolongation, Torsade de Pointes
• Postmarketing reports: Cardiac arrest, cardiac arrhythmias, edema, hypotension, ventricular arrhythmias, ventricular fibrillation, ventricular tachycardia^[Ref]

Hypersensitivity

• Frequency not reported: Hypersensitivity reaction
• Postmarketing reports: Allergic reaction, anaphylactic shock, angioedema, hypersensitivity^[Ref]

Respiratory

• Frequency not reported: Respiratory depression
• Postmarketing reports: Bronchospasm^[Ref]

Dermatologic

• Postmarketing reports: Acute generalized exanthematous pustulosis (AGEP), bullous condition (pemphigoids, toxic epidermal necrolysis), dermatitis, erythema, erythema multiforme, fixed drug eruptions, increased sweating, maculopapular rash, pruritus, rash, Stevens-Johnson syndrome, urticaria^[Ref]

Psychiatric

• Postmarketing reports: Aggression, agitation, confusion, depression, disorientation, hallucination, insomnia, tics^[Ref]

Genitourinary

• Postmarketing reports: Dysuria, enuresis, urinary retention^[Ref]

Ocular

• Postmarketing reports: Accommodation disorder, blurred vision, oculogyric crisis^[Ref]

Hepatic

• Postmarketing reports: Hepatitis, liver function tests abnormal^[Ref]

Hematologic

• Postmarketing reports: Thrombocytopenia^[Ref]

Metabolic

• Postmarketing reports: Weight gain^[Ref]

Frequently asked questions

• Can you take hydroxyzine for anxiety and sleep?
• Does Benadryl help with or cause anxiety?
• Can hydroxyzine be taken long-term?
• When can I start drinking if I’m no longer taking hydroxyzine?
• Can dogs take hydroxyzine?
• Can you take antihistamines when pregnant?

Further information

Hyzine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer