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Hiberix Side Effects

Generic name: haemophilus b conjugate (prp-t) vaccine

Medically reviewed by Last updated on Nov 25, 2023.

Note: This document contains side effect information about haemophilus b conjugate (prp-t) vaccine. Some dosage forms listed on this page may not apply to the brand name Hiberix.

Applies to haemophilus b conjugate (prp-t) vaccine: intramuscular powder for solution, intramuscular powder for suspension, intramuscular solution.

Serious side effects of Hiberix

Along with its needed effects, haemophilus b conjugate (prp-t) vaccine (the active ingredient contained in Hiberix) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking haemophilus b conjugate (prp-t) vaccine:

More common

Less common


Incidence not known

Other side effects of Hiberix

Some side effects of haemophilus b conjugate (prp-t) vaccine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to haemophilus b conjugate (prp-t) vaccine: intramuscular powder for injection.


The most common adverse events were pain and redness at the injection site, irritability, drowsiness, fever, loss of appetite, fussiness, and restlessness. Most symptoms occur in the first 48 hours, are mild, and resolve spontaneously.[Ref]


Very common (10% or more): Pain (49.4%), redness (29.4%), tenderness (20%), swelling (18.7%)

Common (1% to 10%): Induration

Very rare (less than 0.01%): Extensive swelling of vaccinated limb, injection site induration[Ref]

Nervous system

Very common (10% or more): Drowsiness (59.9%), decreased activity/lethargy (51.1%), sleepiness (19.9%)

Rare (less than 0.1%): Seizure with apnea, convulsion

Very rare (less than 0.01%): Convulsions (with or without fever), hypotonic-hyporesponsive episode (e.g. sudden onset of hypotonia, hyporesponsiveness, and pallor or cyanosis), somnolence, syncope, vasovagal responses to injection[Ref]


Very common (10% or more): Irritability (70.4%), fussiness (25.9%), restlessness (21.8%)

Common (1% to 10%): Nervousness

Uncommon (0.1% to 1%): Emotional lability, insomnia[Ref]


Very common (10% or more): Inconsolable crying (58.5%), fever (34.8%)

Common (1% to 10%): Otitis media

Uncommon (0.1% to 1%): Asthenia, fatigue, injury

Postmarketing reports: Peripheral edema[Ref]


Very common (10% or more): Loss of appetite (28.7%)[Ref]


Very common (10% or more): Diarrhea (14.6%), vomiting

Common (1% to 10%): Gastroenteritis

Uncommon (0.1% to 1%): Abdominal pain[Ref]


Common (1% to 10%): Rash erythematous

Uncommon (0.1% to 1%): Sweating increased, purpura

Very rare (less than 0.01%): Angioedema, rash, urticaria

Postmarketing reports: Pruritus[Ref]


Common (1% to 10%): Rhinitis, coughing, respiratory disorder, upper respiratory tract infection, bronchitis

Rare (less than 0.1%): Bilateral pneumonia

Very rare (less than 0.01%): Apnea in very premature infants[Ref]


Rare (less than 0.1%): Allergic reactions (including anaphylactic and anaphylactoid reactions)

Postmarketing reports: Other allergic/hypersensitivity reactions (including urticaria, angioedema)[Ref]


Uncommon (0.1% to 1%): Spastic paralysis[Ref]


Common (1% to 10%): Conjunctivitis[Ref]


Common (1% to 10%): Viral infection[Ref]

More about Hiberix (haemophilus b conjugate (prp-t) vaccine)

Patient resources

Other brands


Professional resources

Other brands


Related treatment guides


1. Cerner Multum, Inc. UK Summary of Product Characteristics.

2. Cerner Multum, Inc. Australian Product Information.

3. Product Information. ActHIB (Hib) (haemophilus b conjugate (PRP-T) vaccine). sanofi pasteur. 2022.

4. Product Information. Hiberix (Hib) (haemophilus b conjugate (PRP-T) vaccine). GlaxoSmithKline. 2022.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.