Hiberix Side Effects
Generic name: haemophilus b conjugate (prp-t) vaccine
Medically reviewed by Drugs.com. Last updated on Oct 5, 2023.
Note: This document provides detailed information about Hiberix Side Effects associated with haemophilus b conjugate (prp-t) vaccine. Some dosage forms listed on this page may not apply specifically to the brand name Hiberix.
Applies to haemophilus b conjugate (prp-t) vaccine: intramuscular powder for solution, intramuscular powder for suspension, intramuscular solution.
Serious side effects of Hiberix
Along with its needed effects, haemophilus b conjugate (prp-t) vaccine (the active ingredient contained in Hiberix) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking haemophilus b conjugate (prp-t) vaccine:
Less common
- earache
- redness or swelling in the ear
Rare
Incidence not known
- bloating or swelling of the face, arms, hands, lower legs, or feet
- bluish lips or skin
- dizziness
- fast heartbeat
- hives or welts, skin rash
- itching (especially of the feet or hands)
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
- reddening of the skin (especially around the ears)
- swelling of the eyes, face, or inside of the nose
- swollen, painful, or tender lymph glands in the neck, armpit, or groin
- tingling of the hands or feet
- unusual tiredness or weakness (sudden and severe)
- unusual weight gain or loss
Other side effects of Hiberix
Some side effects of haemophilus b conjugate (prp-t) vaccine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- fever less than 102 degrees F (39 degrees C)
- irritability
- redness, pain, swelling, tenderness, or warm feeling at the injection site
- reduced physical activity
- restlessness
- sleepiness
Less common
- prolonged crying lasting more than 4 hours
- unusual high-pitched crying
For healthcare professionals
Applies to haemophilus b conjugate (prp-t) vaccine: intramuscular powder for injection.
General
The most common adverse events were pain and redness at the injection site, irritability, drowsiness, fever, loss of appetite, fussiness, and restlessness. Most symptoms occur in the first 48 hours, are mild, and resolve spontaneously.[Ref]
Local
- Very common (10% or more): Pain (49.4%), redness (29.4%), tenderness (20%), swelling (18.7%)
- Common (1% to 10%): Induration
- Very rare (less than 0.01%): Extensive swelling of vaccinated limb, injection site induration[Ref]
Nervous system
- Very common (10% or more): Drowsiness (59.9%), decreased activity/lethargy (51.1%), sleepiness (19.9%)
- Rare (less than 0.1%): Seizure with apnea, convulsion
- Very rare (less than 0.01%): Convulsions (with or without fever), hypotonic-hyporesponsive episode (e.g. sudden onset of hypotonia, hyporesponsiveness, and pallor or cyanosis), somnolence, syncope, vasovagal responses to injection[Ref]
Psychiatric
- Very common (10% or more): Irritability (70.4%), fussiness (25.9%), restlessness (21.8%)
- Common (1% to 10%): Nervousness
- Uncommon (0.1% to 1%): Emotional lability, insomnia[Ref]
Other
- Very common (10% or more): Inconsolable crying (58.5%), fever (34.8%)
- Common (1% to 10%): Otitis media
- Uncommon (0.1% to 1%): Asthenia, fatigue, injury
- Postmarketing reports: Peripheral edema[Ref]
Metabolic
- Very common (10% or more): Loss of appetite (28.7%)[Ref]
Gastrointestinal
- Very common (10% or more): Diarrhea (14.6%), vomiting
- Common (1% to 10%): Gastroenteritis
- Uncommon (0.1% to 1%): Abdominal pain[Ref]
Dermatologic
- Common (1% to 10%): Rash erythematous
- Uncommon (0.1% to 1%): Sweating increased, purpura
- Very rare (less than 0.01%): Angioedema, rash, urticaria
- Postmarketing reports: Pruritus[Ref]
Respiratory
- Common (1% to 10%): Rhinitis, coughing, respiratory disorder, upper respiratory tract infection, bronchitis
- Rare (less than 0.1%): Bilateral pneumonia
- Very rare (less than 0.01%): Apnea in very premature infants[Ref]
Hypersensitivity
- Rare (less than 0.1%): Allergic reactions (including anaphylactic and anaphylactoid reactions)
- Postmarketing reports: Other allergic/hypersensitivity reactions (including urticaria, angioedema)[Ref]
Musculoskeletal
- Uncommon (0.1% to 1%): Spastic paralysis[Ref]
Ocular
- Common (1% to 10%): Conjunctivitis[Ref]
Immunologic
- Common (1% to 10%): Viral infection[Ref]
References
1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
2. Cerner Multum, Inc. "Australian Product Information."
3. (2022) "Product Information. ActHIB (Hib) (haemophilus b conjugate (PRP-T) vaccine)." sanofi pasteur
4. (2022) "Product Information. Hiberix (Hib) (haemophilus b conjugate (PRP-T) vaccine)." GlaxoSmithKline
More about Hiberix (haemophilus b conjugate (prp-t) vaccine)
- Check interactions
- Compare alternatives
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: bacterial vaccines
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Further information
Hiberix side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.