Fibrin sealant topical Side Effects
For the Consumer
Applies to fibrin sealant topical: solution
Other dosage forms:
Along with its needed effects, fibrin sealant topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking fibrin sealant topical:
Less common- Collection of blood or fluids under the skin
- deep, dark purple bruise
- itching, pain, redness, or swelling of the skin, wound, or treated area
- Blurred vision
- chest pain, discomfort, or tightness
- confusion
- cough
- difficulty breathing
- difficulty swallowing
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast, slow, pounding, or irregular heartbeat or pulse
- flushing, redness of the skin
- hives, itching, skin rash
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- lightheadedness, dizziness, or fainting
- numbness or tingling in the face, arms, or legs
- pain in the chest, groin, or legs, especially the calves
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- severe, sudden headache
- shortness of breath
- slurred speech
- sudden loss of coordination
- sudden, severe weakness or numbness in the arm or leg
- sweating
- trouble healing
- trouble speaking or walking
- unusual tiredness or weakness
- unusually warm skin
Some side effects of fibrin sealant topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known- Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- nausea
For Healthcare Professionals
Applies to fibrin sealant topical: topical kit, topical solution
General
General side effects have been reported including rare reports of serious adverse events such as paralysis and other compressive complications possibly related to the use of fibrin sealant in combination with resorbable hemostatic agents. There have also been rare reports of fatalities following the misadministration of topical thrombin.[Ref]
Hypersensitivity
Hypersensitivity side effects such as anaphylactic and anaphylactoid reactions including shock have been reported rarely.[Ref]
Cardiovascular
Cardiovascular side effects including tachycardia, bradycardia, hypotension, and thromboembolic complications have been reported rarely.[Ref]
Respiratory
Respiratory side effects including severe dyspnea have been reported rarely.[Ref]
Dermatologic
Dermatologic side effects including flush, urticaria, and pruritus have been reported rarely.[Ref]
Gastrointestinal
Gastrointestinal side effects including nausea have been reported rarely.
Other
A D-dimer is a fragment produced during the degradation of a clot. Postoperatively increased D-dimers may result at least partly from the degradation of fibrin sealant.[Ref]
Other side effects including increased D-dimer levels have been reported in a clinical study on cardiovascular surgery, but did not exceed values reported in the literature occurring after this type of surgery.[Ref]
References
1. "Product Information. Tisseel (fibrin sealant topical)." Baxter Healthcare Corporation, Deerfield, IL.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
More about fibrin sealant topical
- Side Effects
- During Pregnancy
- Dosage Information
- Support Group
- En Español
- 0 Reviews – Add your own review/rating
- Drug class: miscellaneous coagulation modifiers
Consumer resources
- Fibrin sealant topical
- Fibrinogen and thrombin, human Topical application (Advanced Reading)
- Fibrinogen/aprotinin and thrombin/calcium chloride Topical application, Route Not Applicable (Advanced Reading)