Fibrin Sealant Topical Side Effects
Medically reviewed by Drugs.com. Last updated on Jun 24, 2025.
Applies to fibrin sealant topical: solution.
Other dosage forms:
Precautions
It is very important that your doctor check you or your child closely while you are receiving this medicine to make sure it is working properly.
This medicine may cause a serious type of allergic reaction, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hives, chest pain, dizziness or lightheadedness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.
This medicine is made from donated human blood. Some human blood products have transmitted certain viruses to people who have received them, although the risk is low. Human donors and donated blood are both tested for viruses to keep the transmission risk low. Talk with your doctor about this risk if you are concerned.
Serious side effects
Along with its needed effects, fibrin sealant topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking fibrin sealant topical:
Less common side effects
- collection of blood or fluids under the skin
- deep, dark purple bruise
- itching, pain, redness, or swelling of the skin, wound, or treated area
Incidence not known
- blurred vision
- chest pain, discomfort, or tightness
- confusion
- cough
- difficulty breathing
- difficulty swallowing
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast, slow, pounding, or irregular heartbeat or pulse
- flushing, redness of the skin
- hives, itching, skin rash
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- lightheadedness, dizziness, or fainting
- numbness or tingling in the face, arms, or legs
- pain in the chest, groin, or legs, especially the calves
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- severe, sudden headache
- shortness of breath
- slurred speech
- sudden loss of coordination
- sudden, severe weakness or numbness in the arm or leg
- sweating
- trouble healing
- trouble speaking or walking
- unusual tiredness or weakness
- unusually warm skin
Other side effects
Some side effects of fibrin sealant topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- nausea
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For healthcare professionals
Applies to fibrin sealant topical: topical kit, topical solution.
General adverse events
General side effects have been reported including rare reports of serious adverse events such as paralysis and other compressive complications possibly related to the use of fibrin sealant in combination with resorbable hemostatic agents. There have also been rare reports of fatalities following the misadministration of topical thrombin.[Ref]
Hypersensitivity
Hypersensitivity side effects such as anaphylactic and anaphylactoid reactions including shock have been reported rarely.[Ref]
Cardiovascular
Cardiovascular side effects including tachycardia, bradycardia, hypotension, and thromboembolic complications have been reported rarely.[Ref]
Respiratory
Respiratory side effects including severe dyspnea have been reported rarely.[Ref]
Dermatologic
Dermatologic side effects including flush, urticaria, and pruritus have been reported rarely.[Ref]
Gastrointestinal
Gastrointestinal side effects including nausea have been reported rarely.
Other
Other side effects including increased D-dimer levels have been reported in a clinical study on cardiovascular surgery, but did not exceed values reported in the literature occurring after this type of surgery.[Ref]
A D-dimer is a fragment produced during the degradation of a clot. Postoperatively increased D-dimers may result at least partly from the degradation of fibrin sealant.[Ref]
References
1. (2008) "Product Information. Tisseel (fibrin sealant topical)." Baxter Healthcare Corporation
More about fibrin sealant topical
- Compare alternatives
- Dosage information
- During pregnancy
- Drug class: miscellaneous coagulation modifiers
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Further information
Fibrin sealant topical side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.