Fertinex Side Effects

Generic name: urofollitropin

Medically reviewed by Drugs.com. Last updated on Nov 18, 2024.

Note: This document provides detailed information about Fertinex Side Effects associated with urofollitropin. Some dosage forms listed on this page may not apply specifically to the brand name Fertinex.

Applies to urofollitropin: injection solution reconstituted.

Serious side effects of Fertinex

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Vaginal bleeding that is not normal.
• Pelvic pain.
• Ovarian hyperstimulation syndrome (OHSS) is a severe side effect that may happen in some women who use this drug. Call your doctor right away if you have severe stomach pain or bloating; very upset stomach, throwing up, or diarrhea; a big weight gain; shortness of breath; or change in how much urine is passed.
• Blood clots have happened with this drug. Sometimes, these blood clots have been deadly. Call your doctor right away if you have chest, arm, back, neck, or jaw pain or pressure; coughing up blood; numbness or weakness on 1 side of your body, trouble speaking or thinking, change in balance, or change in eyesight; shortness of breath; or swelling, warmth, or pain in the leg or arm.

Other side effects of Fertinex

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Irritation where the shot is given.
• Upset stomach.
• Headache.
• Stomach cramps.
• Hot flashes.
• Bloating.
• Belly pain.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

For healthcare professionals

Applies to urofollitropin: injectable powder for injection, intramuscular powder for injection, subcutaneous powder for injection.

General adverse events

The most common adverse events were multi-fetal gestation and birth, abdominal cramps, headache, and ovarian hyperstimulation syndrome (OHSS).^[Ref]

Genitourinary

• Very common (10% or more): Multi-fetal gestation and birth (up to 66.7%), ovarian hyperstimulation syndrome (OHSS) (11.4%)
• Common (1% to 10%): Hot flashes, vaginal hemorrhage, ovarian disorder (pain, cyst), urinary tract infection, cervix disorder, post retrieval pain, uterine spasms, vaginal spotting, breast tenderness, vaginal discharge, infection fungal, pelvic pain
• Frequency not reported: Abnormal ovarian enlargement
• Postmarketing reports: Ovarian enlargement, pelvic pain, hot flushes^[Ref]

Cardiovascular

• Common (1% to 10%): Hypertension^[Ref]

Dermatologic

• Common (1% to 10%): Acne, exfoliative dermatitis, rash^[Ref]

Gastrointestinal

• Very common (10% or more): Abdominal cramps (14%), abdominal pain
• Common (1% to 10%): Nausea, enlarged abdomen, vomiting, diarrhea, constipation, abdominal discomfort^[Ref]

Local

• Common (1% to 10%): Injection site pain and reactions (redness, bruising, swelling, and/or itching)^[Ref]

Metabolic

• Common (1% to 10%): Weight gain, dehydration^[Ref]

Musculoskeletal

• Common (1% to 10%): Neck pain
• Postmarketing reports: Muscle spasm^[Ref]

Nervous system

• Very common (10% or more): Headache (12.7%)^[Ref]

Other

• Common (1% to 10%): Pain, fever, accidental injury^[Ref]

Psychiatric

• Common (1% to 10%): Emotional lability, depression^[Ref]

Respiratory

• Common (1% to 10%): Respiratory disorder, sinusitis
• Postmarketing reports: Nasopharyngitis^[Ref]

Hypersensitivity

• Frequency not reported: Allergic, local or generalized skin reactions, delayed-type hypersensitivity^[Ref]

Further information

Fertinex side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer