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Ethyol Side Effects

Generic name: amifostine

Medically reviewed by Last updated on May 14, 2023.

Note: This document contains side effect information about amifostine. Some dosage forms listed on this page may not apply to the brand name Ethyol.

Applies to amifostine: intravenous powder for solution.

Serious side effects of Ethyol

Along with its needed effects, amifostine (the active ingredient contained in Ethyol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking amifostine:

More common


Incidence not known

Other side effects of Ethyol

Some side effects of amifostine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

Incidence not known

For Healthcare Professionals

Applies to amifostine: intravenous powder for injection.


Very common (10% or more): Hypotension (62%)

Rare (less than 0.1%): Chest pain, myocardial ischemia, myocardial infarction, cardiac arrest, exacerbation of preexisting hypertension, tachycardia, bradycardia

Frequency not reported: Flushing/feeling of warmth, arrhythmias (e.g., atrial fibrillation/flutter, supraventricular tachycardia) sometimes associated with hypotension or hypersensitivity[Ref]


Very common (10% or more): Nausea (96%), vomiting

Frequency not reported: Hiccups, diarrhea[Ref]


Frequency not reported: Chills/feeling of coldness, malaise, pyrexia, somnolence, rigors[Ref]


Frequency not reported: Severe hypersensitivity[Ref]


Rare (0.01% to 0.1%): Erythema multiforme, drug reaction with eosinophilia and systematic symptoms (DRESS), Stevens-Johnson Syndrome, toxic epidermal necrolysis (TEN)

Very rare (less than 0.01%): Toxicoderma, bullous dermatitis, exfoliative dermatitis

Frequency not reported: Rash/erythema, pruritus, urticaria, inflammation, cutaneous eruptions[Ref]

Nervous system

Rare (less than 0.1%): Seizures, syncope

Frequency not reported: Dizziness[Ref]


Common (1% to 10%): Hypocalcemia[Ref]


Frequency not reported: Injection site pain, injection site bruising, injection site

Swelling, phlebitis[Ref]


Frequency not reported: Diplopia, blurred vision[Ref]


Rare (less than 0.1%): Dyspnea, apnea, hypoxia, respiratory arrest, laryngeal edema

Frequency not reported: Sneezing, cough[Ref]


Rare (less than 0.1%): Renal failure[Ref]


1. Product Information. Ethyol (amifostine). Alza. 2001;PROD.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.