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Difelikefalin Side Effects

Medically reviewed by Last updated on Nov 28, 2022.

Applies to difelikefalin: intravenous solution.

Serious side effects of Difelikefalin

Along with its needed effects, difelikefalin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking difelikefalin:

More common

Less common

Other side effects of Difelikefalin

Some side effects of difelikefalin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to difelikefalin: intravenous solution.


The more commonly reported adverse effects have included diarrhea, dizziness, nausea, gait disturbances, including falls, hyperkalemia, headache, somnolence, and mental status changes.[Ref]


Common (1% to 10%): Diarrhea, nausea


Common (1% to 10%): Hyperkalemia

Nervous system

Common (1% to 10%): Dizziness, gait disturbances, headache, somnolence, mental status changes


1. "Product Information. Korsuva (difelikefalin)." Cara Therapeutics, Inc. (2021):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.