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Difelikefalin Dosage

Medically reviewed by Last updated on Oct 19, 2023.

Applies to the following strengths: 50 mcg/mL

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Pruritus

0.5 mcg/kg IV at the end of each hemodialysis (HD) treatment


Use: For the treatment of moderate-to-severe pruritus associated with chronic kidney disease in adults undergoing HD

Renal Dose Adjustments

For use in patients undergoing HD.

Liver Dose Adjustments

Mild to moderate hepatic impairment: No adjustment recommended.
Severe hepatic impairment: Use is not recommended.



Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Hemodialysis: Dose should be administered after dialysis.
Peritoneal dialysis: Use is not recommended.

Other Comments

Administration advice:

MISSED DIALYSIS TREATMENT: If a regularly scheduled HD treatment is missed, resume with the next HD treatment.

Storage requirements:

Reconstitution/preparation techniques:


Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.