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Calcium Disodium Versenate Side Effects

Generic Name: edetate calcium disodium

Note: This page contains information about the side effects of edetate calcium disodium. Some of the dosage forms included on this document may not apply to the brand name Calcium Disodium Versenate.

For the Consumer

Applies to edetate calcium disodium: injectable solution

Get emergency medical help if you have any of these signs of an allergic reaction while taking edetate calcium disodium (the active ingredient contained in Calcium Disodium Versenate) hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have:

  • little or no urinating;

  • a light-headed feeling, like you might pass out;

  • numbness or tingly feeling;

  • pink or red urine;

  • feeling very thirsty; or

  • fever, chills, pale skin, easy bruising.

Edetate calcium disodium can have toxic effects in the body, which may cause life-threatening medical problems. Call your doctor at once if you have memory problems, mood changes, trouble concentrating, changes in behavior or mental status, or if you feel irritable.

Common side effects may include:

  • pain where the medicine was injected;

  • fever, chills, general ill feeling, tired feeling;

  • muscle or joint pain;

  • headache, tremors;

  • nausea, vomiting, loss of appetite;

  • sneezing, stuffy nose, watery eyes; or

  • mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to edetate calcium disodium: compounding powder, injectable solution


Cardiovascular side effects have included hypotension and cardiac rhythm irregularities.[Ref]


Gastrointestinal side effects have included cheilosis, nausea, vomiting, anorexia, and excessive thirst.[Ref]


General side effects have included pain at the intramuscular injection site, fever, chills, malaise, and fatigue.[Ref]


Genitourinary side effects have included glycosuria, proteinuria, microscopic hematuria, and large epithelial cells in urinary sediment.[Ref]


Hematologic side effects have included transient bone marrow depression and anemia.[Ref]


Hepatic side effects are mild increases in SGOT and SGPT, which are common, and return to normal within 48 hours after cessation of therapy.[Ref]


Hypersensitivity side effects have included histamine-like reactions and rash.[Ref]


Immunologic side effects have included histamine-like reactions (sneezing, nasal congestion, and lacrimation) and rash.[Ref]


Metabolic side effects have included zinc deficiency and hypercalcemia.[Ref]


Musculoskeletal side effects have included myalgia and arthralgia.[Ref]

Nervous system

Nervous system side effects have included tremors, headache, numbness, and tingling.[Ref]


Renal side effects have included acute necrosis of proximal tubules (which may result in fatal nephrosis) and infrequent changes in distal tubules and glomeruli.[Ref]


1. "Product Information. Calcium Disodiuim Versenate (edetate calcium disodium)." 3M Pharmaceuticals, St Paul, MN.

Not all side effects for Calcium Disodium Versenate may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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