Bexarotene topical Side Effects
Commonly reported side effects of bexarotene topical include: contact dermatitis, dermatological disease, pruritus, and skin rash. Other side effects include: exfoliative dermatitis, and maculopapular rash. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to bexarotene topical: topical gel/jelly
Along with its needed effects, bexarotene topical may cause some unwanted effects. Some side effects will have signs or symptoms that you can see or feel. Your doctor may watch for others by doing certain tests. Since the medication is applied externally to the skin, in general, these side effect are less common. Although not all of these side effects may occur, if they do occur they may need medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking bexarotene topical:More common:
- Bloating or swelling of face, hands, lower legs and/or feet
- chills, fever, or general feeling of discomfort or illness
- decreased urination
- lack or loss of strength
- rapid or unusual weight gain
- skin rash, blisters, redness, or irritation
- sticky or tacky sensation
- thickened, scaly skin
- tingling or “pins and needles” sensation
- sore throat
- swollen, painful or tender lymph glands in neck, armpit, or groin
- unusual bruising
- unusual tiredness or weakness.
Minor Side Effects
Some of the side effects that can occur with bexarotene topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:More common:
- Abnormal or excessive sweating
- blistering, burning, crusting, dryness, flaking, itching, scaling, severe redness, soreness, or swelling of skin or lesion
- increased cough
- lower back or side pain
- painful or difficult urination
For Healthcare Professionals
Applies to bexarotene topical: topical gel
Dermatologic side effects have included rash (56% to 72%), pruritus (18% to 36%), skin disorder (18% to 26%), contact dermatitis (8% to 14%), exfoliative dermatitis (6%), maculopapular rash (6%), and sweating (6%).[Ref]
General side effects have included headache (14%), asthenia (6%), infection (18%), and pain (30%).[Ref]
Metabolic side effects have included hyperlipidemia in 10% of patients.[Ref]
Cardiovascular side effects have included edema (10%) and peripheral edema (6%).[Ref]
Hematologic side effects have included leukopenia and abnormal WBC each reported in 6% of patients.[Ref]
Lymphatic side effects have included lymphadenopathy (6%).[Ref]
Nervous system side effects have included paresthesia (6%).[Ref]
Respiratory side effects have included increased cough and pharyngitis in 6% of patients.[Ref]
1. Leoung GS, Aboulafla D, Millikan L, Duvic M, MacGregor RR, Gill G, Truglia J, Yocum R "Treatment of Kaposi's sarcoma using Targretin (LGD1069), a topical retinoid gel." Int Conf AIDS 11 (1996): 98(ab.no.we.b.3241)
2. "Product Information. Targretin (bexarotene topical)" Stiefel Laboratories Inc, Coral Gables, FL.
Not all side effects for bexarotene topical may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
More about bexarotene topical
- Other brands: Targretin Gel
Related treatment guides
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