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Bexarotene topical Side Effects

In Summary

Commonly reported side effects of bexarotene topical include: contact dermatitis, dermatological disease, pruritus, and skin rash. Other side effects include: exfoliative dermatitis, and maculopapular rash. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to bexarotene topical: topical gel/jelly

Along with its needed effects, bexarotene topical may cause some unwanted effects. Some side effects will have signs or symptoms that you can see or feel. Your doctor may watch for others by doing certain tests. Since the medication is applied externally to the skin, in general, these side effect are less common. Although not all of these side effects may occur, if they do occur they may need medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking bexarotene topical:

More common:
  • Bloating or swelling of face, hands, lower legs and/or feet
  • chills, fever, or general feeling of discomfort or illness
  • decreased urination
  • lack or loss of strength
  • rapid or unusual weight gain
  • skin rash, blisters, redness, or irritation
  • sticky or tacky sensation
  • thickened, scaly skin
  • tingling or “pins and needles” sensation
  • sore throat
  • swollen, painful or tender lymph glands in neck, armpit, or groin
  • unusual bruising
  • unusual tiredness or weakness.

Minor Side Effects

Some of the side effects that can occur with bexarotene topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Abnormal or excessive sweating
  • blistering, burning, crusting, dryness, flaking, itching, scaling, severe redness, soreness, or swelling of skin or lesion
  • headache
  • increased cough
  • lower back or side pain
  • painful or difficult urination

For Healthcare Professionals

Applies to bexarotene topical: topical gel

Dermatologic

Dermatologic side effects have included rash (56% to 72%), pruritus (18% to 36%), skin disorder (18% to 26%), contact dermatitis (8% to 14%), exfoliative dermatitis (6%), maculopapular rash (6%), and sweating (6%).[Ref]

General

General side effects have included headache (14%), asthenia (6%), infection (18%), and pain (30%).[Ref]

Metabolic

Metabolic side effects have included hyperlipidemia in 10% of patients.[Ref]

Cardiovascular

Cardiovascular side effects have included edema (10%) and peripheral edema (6%).[Ref]

Hematologic

Hematologic side effects have included leukopenia and abnormal WBC each reported in 6% of patients.[Ref]

Other

Lymphatic side effects have included lymphadenopathy (6%).[Ref]

Nervous system

Nervous system side effects have included paresthesia (6%).[Ref]

Respiratory

Respiratory side effects have included increased cough and pharyngitis in 6% of patients.[Ref]

References

1. Leoung GS, Aboulafla D, Millikan L, Duvic M, MacGregor RR, Gill G, Truglia J, Yocum R "Treatment of Kaposi's sarcoma using Targretin (LGD1069), a topical retinoid gel." Int Conf AIDS 11 (1996): 98(ab.no.we.b.3241)

2. "Product Information. Targretin (bexarotene topical)" Stiefel Laboratories Inc, Coral Gables, FL.

Not all side effects for bexarotene topical may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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