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Ascor L 500 Side Effects

Generic name: ascorbic acid

Medically reviewed by Last updated on May 3, 2024.

Note: This document contains side effect information about ascorbic acid. Some dosage forms listed on this page may not apply to the brand name Ascor L 500.

Applies to ascorbic acid: oral capsule, oral capsule extended release, oral liquid, oral powder, oral powder for solution, oral powder for suspension, oral solution, oral tablet, oral tablet chewable, oral tablet extended release, oral wafer. Other dosage forms:

Serious side effects of Ascor L 500

Along with its needed effects, ascorbic acid (the active ingredient contained in Ascor L 500) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking ascorbic acid:

Less common or rare

- with high doses

Other side effects of Ascor L 500

Some side effects of ascorbic acid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

- with high doses

For Healthcare Professionals

Applies to ascorbic acid: compounding powder, injectable solution, intravenous solution, oral capsule, oral capsule extended release, oral gum, oral liquid, oral tablet, oral tablet chewable, oral tablet disintegrating, oral tablet extended release.


Renal side effects have included oxalate and urate kidney stones.[Ref]

Hyperoxaluria appears to be dose-related.[Ref]

Nervous system

Nervous system side effects have included dizziness, faintness, fatigue, and headache in less than 1% of patients. Migraine headache has also been reported.[Ref]

Migraine headache has been reported with a daily dose of 6 grams.

The manufacturer reports temporary dizziness and faintness may be associated with too rapid of a rate during intravenous administration.[Ref]


Other side effects have included flank pain in less than 1% of patients. Conditional scurvy has also been reported.[Ref]

Conditional scurvy is reported to occur following excessive doses of ascorbic acid over a prolonged period of time. The mechanism of action for this condition is thought to be that large doses of ascorbic acid condition the patient over time for rapid clearance of ascorbic acid resulting in scurvy. The plasma levels of ascorbic acid appear to remain within normal limits. The actual existence of conditional scurvy remains controversial.[Ref]


Gastrointestinal side effects have included nausea, diarrhea, abdominal cramps, and esophagitis.[Ref]

Nausea, diarrhea, and abdominal cramps appears to be associated with doses exceeding 2 g per day, although there have been some reports with as little as 1 g per day.

Esophagitis appears to be associated with prolonged or increased contact of ascorbic acid tablets with the esophageal mucosa.[Ref]


Hematologic side effects have included hemolysis.[Ref]

The majority of hemolysis reports have been associated with patients who have concurrent glucose-6-phosphate dehydrogenase deficiency.[Ref]


Local side effects have included transient mild soreness at the site of injection.[Ref]


1. Levine M, Dhariwal KR, Welch RW, Wang Y, Park JB (1995) "Determination of optimal vitamin C requirements in humans." Am J Clin Nutr, 62(6 Suppl), s1347-56

2. Hathcock JN (1997) "Vitamins and minerals: Efficacy and safety." Am J Clin Nutr, 66, p. 427-37

3. (1999) "How much vitamin C do you need?" JAMA, 281, p. 1460

4. "Product Information. Cemill 500 (ascorbic acid)." Abbott Pharmaceutical

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.