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A-25 Side Effects

Generic name: vitamin a

Medically reviewed by Last updated on May 16, 2024.

Note: This document contains side effect information about vitamin a. Some dosage forms listed on this page may not apply to the brand name A-25.

Applies to vitamin a: capsule, capsule liquid filled, solution, tablet.

Serious side effects of A-25

Along with its needed effects, vitamin a (the active ingredient contained in A-25) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vitamin a:

Check with your doctor as soon as possible if any of the following side effects occur while taking vitamin a:

For Healthcare Professionals

Applies to vitamin a: intramuscular solution, oral capsule, oral liquid.


Frequency not reported: Hypervitaminosis A syndrome[Ref]

Hypervitaminosis A:

General manifestations: fatigue, malaise, lethargy, abdominal discomfort, anorexia, vomiting.

Specific manifestations:

-Skeletal: hard tender cortical thickening over the radius and tibia, migratory arthralgia, slow growth, premature closer of the epiphysis leading to arrested bone growth in children

-Central nervous system: irritability, headache, increased intracranial pressure manifested by bulging fontanels, papilledema, and exophthalmos

-Dermatologic: fissures of the lips, drying and cracking of the skin, alopecia, scaling, massive desquamation, increased pigmentation

-Systemic: hypomenorrhea, hepatosplenomegaly, hepatotoxicity, jaundice, leukopenia, vitamin A plasma level over 1200 Units/mL[Ref]


Frequency not reported: Acute toxicity (single dose of 25,000 Units/kg), chronic toxicity (4000 Units/kg for 6 to 15 months)[Ref]

Acute toxicity occurs at single doses of 350,000 units for infants and at over 2 million units for adults.

Chronic toxicity occurs in infants (3 to 6 months) at 8,500 Units per day for 1 to 3 months, and in adults at 1 million Units daily for 3 days, at 500,000 Units daily for 2 months, or 50,000 units daily for over 18 months.[Ref]


Frequency not reported: Anaphylactic shock and death (intravenous)[Ref]

Frequently asked questions

More about A-25 (vitamin a)

Patient resources

Other brands

Aquasol A

Professional resources

Other brands

Aquasol A

Related treatment guides


1. (2022) "Product Information. Aquasol A (vitamin A)." Hospira Inc

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.