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Oxymetazoline (Ophthalmic)

Pronunciation

(oks i met AZ oh leen)

Index Terms

  • Oxymetazoline HCl
  • Oxymetazoline Hydrochloride

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Solution, Ophthalmic, as hydrochloride:

Visine-LR: 0.025% (15 mL [DSC]) [contains benzalkonium chloride]

Brand Names: U.S.

  • Visine-LR [OTC] [DSC]

Pharmacologic Category

  • Imidazoline Derivative
  • Vasoconstrictor

Onset of Action

5-10 minutes (Duzman, 1983)

Duration of Action

Up to 6 hours

Use: Labeled Indications

Relief of redness of eye due to minor eye irritations

Contraindications

Hypersensitivity to oxymetazoline or any component of the formulation

Dosing: Adult

Relief of eye redness: Ophthalmic: Instill 1-2 drops in affected eye(s) every 6 hours as needed or as directed by healthcare provider for ≤72 hours

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Relief of eye redness: Ophthalmic: Children ≥6 years: Instill 1-2 drops in affected eye(s) every 6 hours as needed or as directed by healthcare provider for ≤72 hours

Administration

Remove contact lenses before use. Do not touch tip of container to eye or any surface. Replace cap after each use.

Storage

Store at controlled room temperature of 15°C to 25°C (59°F to 77°F).

Drug Interactions

There are no known significant interactions.

Adverse Reactions

Frequency not defined.

Local: Transient burning, stinging

Warnings/Precautions

Disease-related concerns:

• Glaucoma: May exacerbate condition; use caution.

Other warnings/precautions:

• Accidental ingestion: Accidental ingestion by children of over-the-counter (OTC) imidazoline-derivative eye drops and nasal sprays may result in serious harm. Serious adverse reactions (eg, coma, bradycardia, respiratory depression, sedation) requiring hospitalization have been reported in children ≤5 years of age who had ingested even small amounts (eg, 1-2 mL). Contact a poison control center and seek emergency medical care immediately for accidental ingestion (FDA Drug Safety Communication, 2012).

Patient Education

• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

• Have patient report immediately to prescriber vision changes, eye pain, or severe eye irritation (HCAHPS).

• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.

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