Bacitracin Zinc / Neomycin Sulfate / Polymyxin B Sulfate / Hydrocortisone
Pronunciation: Bass-ih-TRAY-sin zingk/NEE-oh-MY-sin SULL-fate/pal-ee-MIX-in BEE SULL-fate/HIGH-droe-CORE-tih-sone
Class: Antibiotic, Corticosteroid
- Ointment 400 units/g bacitracin zinc, 3.5 mg/g neomycin, 5,000 units/g polymyxin B, 1% hydrocortisone
Inhibits protein synthesis by binding to ribosomal RNA, causing bacterial genetic code misreading.Polymyxin B
Interacts with phospholipid components of bacterial cell membrane, increasing cell wall permeability.Bacitracin
Interferes with bacterial cell wall synthesis by inhibiting regeneration of phospholipid receptors involved with paptidoglycan synthesis.Hydrocortisone
Suppresses inflammatory response.
Indications and Usage
Treatment of corticosteroid-responsive dermatoses with secondary infection.
Use in the eyes or external ear canal (if the eardrum is perforated); tuberculosis; fungal or viral (eg, varicella zoster) lesions of the skin; hypersensitivity to any of components of product.
Dosage and Administration
Topical Apply thin film to affected area 2 to 4 times daily, not to exceed 7 days.
Store at controlled room temperature (59° to 86°F). Keep tube tightly closed.
None well documented.
Laboratory Test Interactions
None well documented.
Acneiform eruption, allergic contact dermatitis, burning, dryness, folliculitis, hypertrichosis, hypopigmentation, itching, maceration of the skin, miliaria, perioral dermatitis, secondary infection, skin atrophy, skin sensitization, striae.
Category C .
Hydrocortisone is excreted in breast milk following oral administration.
Safety and efficacy in children not established.
Prolonged use may result in bacterial or fungal overgrowth of nonsusceptible microorganisms.
Signs and symptoms of exogenous hyperadrenocorticism can occur with use of topical corticosteroids, especially if occlusive dressings are used.
Bacterial resistance to components of the product may develop.
- Review prescribed dosing schedule with patient or caregiver.
- Remind patient or caregiver that ointment is not to be used in the eye or ear (if the eardrum is perforated).
- Teach patient or caregiver proper technique for applying ointment: Wash hands; apply thin film to affected area(s) using fingers or applicator. Wash hands after applying ointment.
- Advise patient or caregiver to contact health care provider if local redness or swelling develops or if skin lesions do not improve or worsen.
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