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Wheat, Gluten May Be Safe to Consume for Many With IBS and Self-Perceived Sensitivity

By Elana Gotkine HealthDay Reporter

Medically reviewed by Carmen Pope, BPharm. Last updated on July 25, 2025.

FRIDAY, July 25, 2025 -- Patients with irritable bowel syndrome (IBS) with self-perceived gluten sensitivity react similarly to wheat, gluten, and sham challenges, according to a study published online July 21 in The Lancet Gastroenterology & Hepatology.

Caroline Larissa Seiler, Ph.D., from McMaster University in Hamilton, Ontario, Canada, and colleagues conducted a randomized, double-blind, sham-controlled crossover study involving adults who met Rome IV criteria for IBS and had previously self-reported improvement on a gluten-free diet. Eligible participants were randomly assigned to receive one of six sequences of wheat, gluten, and sham (gluten- and wheat-free flour) cereal bars in three periods of seven days separated by a 14-day washout period. Twenty-nine participants were enrolled and randomly assigned; 28 completed the study.

The researchers observed no significant differences in the proportion of participants with a worsening of IBS symptoms of at least 50 points on the IBS Symptom Severity Score after wheat or gluten versus sham (39 and 36 percent, respectively, versus 29 percent). Adverse events were reported in 93, 93, and 93 percent of patients after wheat, gluten, and sham, respectively. Between challenges, study-emergent adverse events were similar (18, 18, and 25 percent after wheat, gluten, and sham, respectively). There were no reports of severe adverse events.

"Not every patient who believes they are reacting to gluten actually does," senior author Premysl Bercik, M.D., also from McMaster University, said in a statement. "Some truly have a sensitivity to this food protein, but for many others, it's the belief itself that's driving their symptoms and subsequent choices to avoid gluten-containing foods."

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Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.

Posted July 2025

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