Vaccination of 27- to 45-Year-Olds Against HPV Is Less Cost-Effective
By Elana Gotkine HealthDay Reporter
TUESDAY, Nov. 26, 2024 -- Vaccination of 27- to 45-year-olds ("mid-adults") against human papillomavirus (HPV) is less cost-effective than vaccination of younger persons (aged 9 to 26 years), according to a study published online Nov. 26 in the Annals of Internal Medicine.
Jean-François Laprise, Ph.D., from the Centre de recherche du CHU de Québec-Université Laval in Québec City, and colleagues examined the incremental cost-effectiveness ratios (ICERs) and number needed to vaccinate (NNV) to prevent one HPV-related cancer case for expanding HPV vaccination to subgroups of mid-adults and those at higher risk.
The researchers found that the projected costs increased by $2,005,000, $763,000, and $1,164,000 per quality-adjusted life-year (QALY) gained for expanding 9-valent HPV vaccination to all mid-adults, those with more lifetime partners, and those who have just separated, respectively. To prevent one additional HPV-related cancer case, the NNVs were 7,670, 3,190, and 5,150, respectively, compared with 223 for vaccination of those aged 9 to 26 years. In the sensitivity analysis, vaccinating infrequently screened mid-adult women who have just separated and have a higher number of lifetime sex partners was the mid-adult strategy with the lowest ICER and NNV (ICER, $86,000 per QALY gained; NNV, 470).
"HPV vaccination of mid-adults remains much less cost-effective and produces much higher NNVs than vaccinating females and males aged 26 years or younger under all scenarios investigated," the authors write.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.
Posted November 2024
Read this next
COVID-19 Tied to Higher Risk for Inflammatory Diseases of the Airways
THURSDAY, Aug. 28, 2025 -- People who have had COVID-19 have an increased risk for developing certain new-onset type 2 inflammatory diseases of the airways, while receipt of a...
Tdap, MenACWY Coverage Increased in Teens From 2023 to 2024
TUESDAY, Aug. 19, 2025 -- From 2023 to 2024, coverage with one or more doses of the tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) and the...
Two Doses of Zoster Vaccine Reduce Risk for Herpes Zoster Ophthalmicus
TUESDAY, Aug. 19, 2025 -- Two doses of recombinant zoster vaccine (RZV) are associated with a reduced risk for herpes zoster ophthalmicus (HZO), acute myocardial infarction, and...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.