Vaccination of 27- to 45-Year-Olds Against HPV Is Less Cost-Effective
By Elana Gotkine HealthDay Reporter
TUESDAY, Nov. 26, 2024 -- Vaccination of 27- to 45-year-olds ("mid-adults") against human papillomavirus (HPV) is less cost-effective than vaccination of younger persons (aged 9 to 26 years), according to a study published online Nov. 26 in the Annals of Internal Medicine.
Jean-François Laprise, Ph.D., from the Centre de recherche du CHU de Québec-Université Laval in Québec City, and colleagues examined the incremental cost-effectiveness ratios (ICERs) and number needed to vaccinate (NNV) to prevent one HPV-related cancer case for expanding HPV vaccination to subgroups of mid-adults and those at higher risk.
The researchers found that the projected costs increased by $2,005,000, $763,000, and $1,164,000 per quality-adjusted life-year (QALY) gained for expanding 9-valent HPV vaccination to all mid-adults, those with more lifetime partners, and those who have just separated, respectively. To prevent one additional HPV-related cancer case, the NNVs were 7,670, 3,190, and 5,150, respectively, compared with 223 for vaccination of those aged 9 to 26 years. In the sensitivity analysis, vaccinating infrequently screened mid-adult women who have just separated and have a higher number of lifetime sex partners was the mid-adult strategy with the lowest ICER and NNV (ICER, $86,000 per QALY gained; NNV, 470).
"HPV vaccination of mid-adults remains much less cost-effective and produces much higher NNVs than vaccinating females and males aged 26 years or younger under all scenarios investigated," the authors write.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted November 2024
Read this next
Study Estimates COVID-19 Vaccinations Prevented More Than 2.5 Million Deaths in 2020 to 2024
MONDAY, Aug. 4, 2025 -- COVID-19 vaccination during 2020 to 2024 was beneficial, but estimates are more conservative than previous calculations that focused on the first year of...
COVID-19 Vaccine Boosters Aid Outcomes in Patients With Cancer
TUESDAY, July 29, 2025 -- COVID-19 vaccination boosters protect people with cancer developing from severe COVID-19, according to a study published online July 17 in JAMA...
35 Percent of Eligible Children Receive RSV Prophylaxis With Nirsevimab
TUESDAY, July 22, 2025 -- Despite near universal availability of nirsevimab, only 35 percent of eligible children receive nirsevimab for respiratory syncytial virus (RSV)...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.