Urine Albumin-to-Creatinine Ratio Indicates Risk in Rheumatoid Arthritis
By Elana Gotkine HealthDay Reporter
THURSDAY, Oct. 10, 2024 -- For patients with rheumatoid arthritis (RA), urine albumin-to-creatinine ratio (ACR) is an independent risk factor indicating prognosis, according to a study published online Sept. 18 in Frontiers in Immunology.
Zexuan Bin, from The Second Hospital of Shanxi Medical University in Taiyuan, China, and colleagues used 2009 to 2018 data from the National Health and Nutrition Examination Survey to examine whether ACR is an independent risk factor influencing prognosis in RA patients. The cumulative survival probability of RA patients with different urinary albumin excretion was compared.
The researchers found that RA patients with microalbuminuria had a significant increase in all-cause mortality in the Cox regression model adjusted with covariates (hazard ratio, 1.53) and a nonsignificant increase in cardiovascular disease mortality. ACR ≥300 mg/g was associated with increased all-cause and cardiovascular disease mortality (hazard ratios, 2.62 and 5.67, respectively). A nonlinear correlation between ACR and all-cause mortality was seen in RA patients with microalbuminuria in a restricted cubic spline analysis. Cardiovascular disease mortality was higher in RA patients with microalbuminuria who were female; had other ethnicity; and had estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2, hypertension, or hyperlipidemia. ACR provided better prognostic efficacy than eGFR, with higher values of area under the curve for all-cause and cardiovascular disease mortality (0.683 and 0.681, respectively).
"ACR was closely related to the prognosis of RA patients and could be considered as a sensitive and independent indicator for physicians to predict the mortality especially cardiovascular disease mortality in the process of diagnosis and treatment," the authors write.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted October 2024
Read this next
Random Forest AI Model Superior for Inpatient Mortality Prognostication in Cirrhosis
THURSDAY, July 24, 2025 -- For inpatients with cirrhosis, a machine learning (ML) model using random forest (RF) analysis is superior for prediction of inpatient mortality...
Inflammation and Nutrition-Based Scores Tied to Prognosis of Low-Risk Myelodysplastic Syndrome
THURSDAY, July 24, 2025 -- The Prognostic Nutritional Index (PNI) and systemic oxidative stress (SOS) score are independently associated with poorer prognosis of low-risk...
Few School Principals Report District-Mandated Mental Health Screening
THURSDAY, July 24, 2025 -- Few school principals report district-mandated mental health screening in schools, according to a study published online July 18 in JAMA Network...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.