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Signatures of Disrupted Affective Sound Processing Identified in Tinnitus

Medically reviewed by Carmen Pope, BPharm. Last updated on May 5, 2025.

By Elana Gotkine HealthDay Reporter

MONDAY, May 5, 2025 -- For persons with sound sensitivity and tinnitus, accurate predictors of sensory disorder severity can be identified in pupil dilations and facial movements elicited by emotionally evocative sounds, according to a study published online April 30 in Science Translational Medicine.

Samuel S. Smith, M.D., M.P.H., from Eaton-Peabody Laboratories at Massachusetts Eye and Ear in Boston, and colleagues studied 50 neurotypical adults and 47 adults with a combination of sound sensitivity and tinnitus and identified a new class of objective measurement that could predict individual differences in the Tinnitus Handicap Inventory (THI) and Hyperacusis Questionnaire (HQ).

The researchers found that neurophysiological assessment of central auditory gain demonstrated an elevation in adults with tinnitus and sound sensitivity, but there was no association with the severity of symptoms. Pupil dilations and facial movements elicited by emotionally evocative sounds were accurate predictors of individual THI and HQ scores.

"The affective measures described here were noninvasive and could be measured without specialized equipment, suggesting a promising future alternative to subjective self-report questionnaires in clinical settings," the authors write. "Having identified promising objective measures in our carefully controlled participant cohort, future work will be needed to adapt these approaches to more complex at-risk populations by implementing shorter test durations, lower sound levels, and remote data collection."

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Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

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Posted May 2025

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