Score Can Predict Likelihood of Advanced Colorectal Neoplasia in People Under 45
By Elana Gotkine HealthDay Reporter
TUESDAY, March 18, 2025 -- A simple score using clinical factors can predict the likelihood of advanced colorectal neoplasia (AN) in adults aged younger than 45 years undergoing colonoscopy, according to a study published online Feb. 13 in Digestive Diseases and Sciences.
Sarah Wehbe, M.D., from the Cleveland Clinic, and colleagues conducted a cross-sectional analysis involving adults aged 18 to 44 years who underwent colonoscopy between 2011 and 2021. The case group included those with AN, while those with normal colonoscopy or nonadvanced neoplasia comprised the control group. A model was constructed using backward elimination multivariable logistic regression methods based on significant associations between risk factors and the presence of AN in a randomly selected training set; the associations were confirmed in a validation set.
AN was identified in 346 (3.7 percent) of the 9,446 participants. The researchers found that body mass index, family history of colorectal cancer, and tobacco use were identified as risk factors for AN in the training set. The model exhibited moderate discriminatory power in the validation set (C-statistic, 0.645). The prediction score estimated the likelihood of detecting AN in the complete dataset from 1.8 to >14 percent for individuals scoring 1 and ≥9, respectively.
"The results of the model were used to develop a simple score that estimates the likelihood of detecting advanced colorectal neoplasia," the authors write. "Once externally validated, the score may be useful for individualized colorectal cancer prevention strategies."
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted March 2025
Read this next
Declining Childhood Vaccination May Increase Risk for Vaccine-Preventable Infections
WEDNESDAY, April 30, 2025 -- Declining childhood vaccination rates may increase outbreaks of eliminated vaccine-preventable infections within the United States, leading to a...
AACR: Incidence-Based Mortality Dropping for Young Women With Breast Cancer
TUESDAY, April 29, 2025 -- Incidence-based mortality (IBM) declined from 2010 to 2020 among women aged 20 to 49 years diagnosed with breast cancer, according to a study presented...
AACR: Nonsurgical Treatment Feasible for Mismatch Repair-Deficient Tumors
TUESDAY, April 29, 2025 -- A neoadjuvant programmed cell death 1 (PD-1) blockade enables nonoperative management among patients with early-stage mismatch repair-deficient (dMMR)...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.