Rheumatoid Arthritis Causally Linked to Prostate Cancer
By Elana Gotkine HealthDay Reporter
WEDNESDAY, Jan. 29, 2025 -- Genetically predicted rheumatoid arthritis (RA) is causally associated with prostate cancer (PCa), according to a study published online Jan. 10 in Medicine.
Shihua Ye, from Mindong Hospital Affiliated to Fujian Medical University in China, and colleagues examined the causal association between three common autoimmune diseases: RA, systemic lupus erythematosus (SLE), and ankylosing spondylitis (AS) and the risk for PCa. Genome-wide association studies summary statistics were used to conduct forward and reverse Mendelian randomization (MR). Risk factors, including smoking and obesity, were also incorporated in the multivariable MR analysis.
The researchers found that genetically predicted RA was associated with an increased risk for PCa in a univariable MR analysis (odds ratio, 1.036; 95 percent confidence interval, 1.022 to 1.049). No significant association was seen for SLE or AS with PCa. The positive association between RA and PCa was confirmed in a multivariable MR analysis adjusted for smoking and obesity. No significant inverse causal associations were seen between PCa and the three autoimmune diseases in a reverse MR analysis.
"The positive association between genetically predicted RA and PCa risk found in our study highlights the importance of monitoring PCa risk in patients with RA. Clinicians should be aware of this potential comorbidity and consider including PCa screening in routine checkups for RA patients," the authors write.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted January 2025
Read this next
Risk for Death From Prostate Cancer Low With Guideline Care for Nonmetastatic Disease
MONDAY, July 14, 2025 -- Men with nonmetastatic prostate cancer receiving guideline-concordant care have a much higher risk for death from causes other than prostate cancer...
Novel Exercise May Aid Rheumatoid Arthritis Outcomes
TUESDAY, July 8, 2025 -- A novel form of upper- and lower-body exercise, blood flow-restricted resistance training (BFR-RT), improves outcomes with rheumatoid arthritis (RA)...
Global Incidence Rate of Rheumatoid Arthritis Increased From 1990 to 2021
MONDAY, June 16, 2025 -- The incidence rate of rheumatoid arthritis (RA) increased globally from 1990 to 2021, with the heaviest burden born by regions with a high...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.