Renal Graft Survival Similar for Toxoplasma Ab-Positive, Negative Donors
By Elana Gotkine HealthDay Reporter
FRIDAY, Aug. 16, 2024 -- For recipients of renal transplant, graft survival is similar for Toxoplasma antibody-positive donors (TPD) and Toxoplasma-negative donors, according to a study published online July 11 in Transplant International.
Lavjay Butani, M.D., and Daniel Tancredi, Ph.D., from the University of California Davis Medical Center in Sacramento, used data from the Organ Procurement and Transplant Network database to compare graft survival in deceased donor renal transplant recipients, stratified by Toxoplasma immunoglobulin (Ig)G status. A model for graft failure, categorized by Toxoplasma IgG status, adjusted for confounders, was applied to first kidney-only transplant recipients from 2018 to 2022.
Overall, 4,317 of the 51,422 transplants (8.4 percent) were from TPD. The researchers found that the groups had similar acute rejection and graft failure (5 percent each). Crude graft failure was 7.3 and 6.5 failures per 100 person-years for TPD recipients and for the Toxoplasma-negative group, respectively. The crude failure rate ratio was 1.14, and the adjusted hazard rate ratio was 1.04 (95 percent confidence interval, 0.94 to 1.15; P = 0.39).
"In transplants, kidneys are the greatest need," Butani said in a statement. "Because of increased diabetes, high blood pressure and other conditions, the wait list just gets progressively longer. We hope these findings will help increase the supply of donor kidneys."
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted August 2024
Read this next
GLP-1 RA Use Tied to Better Kidney Transplant Outcomes in Patients With Diabetes
TUESDAY, March 18, 2025 -- Glucagon-like peptide-1 receptor agonist (GLP-1 RA) use is associated with better graft and patient survival among kidney transplant recipients with...
PTLD Up for Seronegative Recipients of Epstein-Barr Virus-Seropositive Donor Kidneys
WEDNESDAY, Feb. 5, 2025 -- Epstein-Barr virus (EBV)-seronegative recipients of EBV-seropositive donor (EBV D+/R−) kidneys have an increased risk for posttransplant...
Kidney Transplant Noninferior From Donors With Versus Without HIV in HIV-Positive Recipients
THURSDAY, Oct. 17, 2024 -- Among recipients with HIV, kidney transplantation from donors with HIV is noninferior to that from donors without HIV, according to a study published...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.