Novel Imaging Technique Accurate for Detecting Clear-Cell Renal Cell Cancer
By Elana Gotkine HealthDay Reporter
MONDAY, Oct. 21, 2024 -- ⁸⁹Zr-labeled monoclonal antibody ([⁸⁹Zr]Zr-girentuximab) for positron emission tomography-computed tomography (PET-CT) is accurate for detecting patients with clear-cell renal cell carcinoma, according to a study published online in the October issue of The Lancet Oncology.
Brian Shuch, M.D., from the University of California Los Angeles, and colleagues conducted a multicenter, phase 3 trial at 36 research hospitals and practices across nine countries to examine [⁸⁹Zr]Zr-girentuximab PET-CT imaging for detection and characterization of clear-cell renal cell carcinoma. Three hundred patients aged 18 years or older with an indeterminate renal mass 7 cm or smaller (cT1) suspicious for clear-cell renal cell carcinoma and scheduled for nephrectomy received a single dose of [⁸⁹Zr]Zr-girentuximab intravenously followed by abdominal PET-CT imaging. Surgery was performed up to 90 days after [⁸⁹Zr]Zr-girentuximab administration.
The primary analysis included 284 of the evaluable patients. The mean sensitivity and specificity of [⁸⁹Zr]Zr-girentuximab PET-CT imaging for detection of clear-cell renal cell carcinoma was 85.5 and 87.0 percent, respectively. There were no safety signals. Most of the adverse events were not or were unlikely to be related to [⁸⁹Zr]Zr-girentuximab; 74 percent of the 261 events occurred during or after surgery. Fifty-two serious adverse events were reported in 25 patients, of which 51 occurred after surgery. No treatment-related deaths occurred.
"Imaging using [⁸⁹Zr]Zr-girentuximab has the potential to change clinical practice in renal cell carcinoma, including staging and monitoring patients at high risk and detection of distant metastasis," the authors write.
Several authors disclosed ties to biopharmaceutical companies, including Telix Pharmaceuticals, which funded the study.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.
Posted October 2024
Read this next
2011 to 2023 Saw Increase in Prevalence of Obesity Among Children
WEDNESDAY, July 2, 2025 -- The prevalence of obesity increased among children and adolescents from 2011 to 2023, with the increase most pronounced among Black youths, according to...
2023 to 2024 COVID-19 Vaccine Provided Additional Effectiveness
WEDNESDAY, July 2, 2025 -- The 2023 to 2024 COVID-19 vaccine provided additional effectiveness against medically attended COVID-19, according to a study published online June 24...
Men With Hidradenitis Suppurativa Perceive Better Physician Communication
WEDNESDAY, July 2, 2025 -- Male patients with hidradenitis suppurativa (HS) perceive better physician communication with respect to demonstrating respect, listening, and...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.