Nicotine Analogue Concentrations Deviate From Labels
By Lori Solomon HealthDay Reporter
TUESDAY, Aug. 13, 2024 -- There are discrepancies between labeled and measured concentrations of nicotine analogues in electronic cigarettes and e-cigarette liquids, according to a research letter published online Aug. 7 in the Journal of the American Medical Association.
Hanno C. Erythropel, Ph.D., from Yale University in New Haven, Connecticut, and colleagues quantified constituents of e-cigarette products containing nicotine analogues to assess product consistency. The analysis included nine available flavors of product 1 labeled as containing 5 percent 6-methylnicotine (6MN) and two flavors of product 2 at four concentrations of nicotinamide (0, 12, 24, and 36 mg/mL) that were purchased between November 2023 and February 2024 from three major online retailers.
The researchers found that 6MN presence was confirmed in all product 1 flavors. Both nicotinamide and 6MN were detected in product 2 samples labeled as containing nicotinamide (six of eight). No sample contained nicotine. Product 1 was labeled as containing 5 percent 6MN (50 mg/g), but the analysis showed it only contained 5.8 to 6.3 mg/g (87 to 88 percent less than labeled). In product 2, samples contained nicotinamide contents 7 to 46 percent less than as labeled. Although product 2 labels did not list 6MN as an ingredient, 6MN was detected (0.06 to 0.17 mg/g) when nicotinamide was present. Product 1 samples contained only the (S)-6MN stereoisomer, which previous research showed is more potent and addictive than the (R) form. Product 1 samples all contained the artificial sweetener neotame (0.20 to 0.86 mg/g) and the synthetic coolant 2-isopropyl-N-2,3-trimethylbutyramide (WS-23; 4.34 to 16.39 mg/g) plus various flavorants, whereas product 2 samples did not contain sweeteners or coolants.
"With e-cigarettes increasingly considered for smoking cessation, the advent of nicotine analogue-containing products with unknown health risks raises concern," the authors write.
Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted August 2024
Read this next
Prevalence of Most Cancer Risk Factors Unchanged Before, After Pandemic
THURSDAY, April 24, 2025 -- Smoking rates continued to decline during the COVID-19 pandemic, but other major risk factors for cancer remained stable, according to a study...
Smoking, Eating, Vaping, Dabbing Are Most Common Routes of Marijuana Use
WEDNESDAY, April 23, 2025 -- Smoking, eating, vaping, and dabbing are the most common routes of marijuana use, according to research published in the April 10 issue of the U.S...
Dual-Use of Cigarettes, E-Cigarettes Tied to Same Toxicant Exposure as Cigarettes Alone
TUESDAY, April 22, 2025 -- Both dual use of traditional and electronic cigarettes and exclusive cigarette use are associated with higher toxicant exposure than exclusive...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.