Multimorbidity Tied to Accelerated Kidney Function Decline in Older Adults
By Lori Solomon HealthDay Reporter
THURSDAY, Dec. 26, 2024 -- Multimorbidity is strongly associated with accelerated kidney function decline in older age, according to a study published online Dec. 17 in the Journal of the American Geriatrics Society.
Giorgi Beridze, M.D., from the Karolinska Institutet and Stockholm University, and colleagues examined the role of multimorbidity (two or more conditions) and the development of kidney function decline. The analysis included data from 3,094 individuals participating in the Swedish National study on Aging and Care in Kungsholmen, who were followed for 15 years.
The researchers found an independent dose-response relationship between the number of chronic conditions and absolute (β = −0.05) and relative (hazard ratio, 1.23) declines in estimated glomerular filtration rate. Five patterns of multimorbidity existed in the cohort. The unspecific, low-burden pattern had the lowest morbidity burden and served as the reference category. The unspecific, high-burden and cardiometabolic patterns showed accelerated absolute (β = −0.15 and −0.77, respectively) and relative declines (hazard ratios, 1.45 and 3.45, respectively). The cognitive and sensory pattern showed accelerated relative decline (hazard ratio, 1.53). There were no associations seen for the psychiatric and respiratory pattern.
"Targeted interventions aimed at individuals with cardiometabolic multimorbidity could help mitigate the risk of kidney function decline in older age," the authors write.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted December 2024
Read this next
Novel Biomarker Risk Prediction Models Examined in Chronic Kidney Disease
FRIDAY, Aug. 22, 2025 -- For adults with nondialysis chronic kidney disease (CKD), risk prediction models incorporating novel biomarkers show comparable discrimination to...
High Metabolic Syndrome Severity Linked to Development of CKD
FRIDAY, Aug. 15, 2025 -- High metabolic syndrome (MetS) severity, expressed by the continuous metabolic syndrome severity score (cMetS-S), is associated with development of...
Lupus Low Disease Activity State Attainable in Lupus Nephritis
THURSDAY, Aug. 14, 2025 -- In lupus nephritis, attainment of complete renal response (CRR)/partial renal response (PRR) and lupus low disease activity state (LLDAS) is associated...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.