High Metabolic Syndrome Severity Linked to Development of CKD
By Elana Gotkine HealthDay Reporter
FRIDAY, Aug. 15, 2025 -- High metabolic syndrome (MetS) severity, expressed by the continuous metabolic syndrome severity score (cMetS-S), is associated with development of chronic kidney disease (CKD), according to a study recently published in Kidney Diseases.
Ladan Mehran, M.D., Ph.D., from the Shahid Beheshti University of Medical Sciences in Tehran, Iran, and colleagues examined the association between the trajectory of cMetS-S and development of CKD in a population-based study involving 4,462 participants aged 20 to 60 years free of CKD at baseline who were followed at three-year intervals. cMetS-S trajectories were examined over nine years (1999 to 2009) and the subsequent risks for incident CKD were assessed eight years later (2010 to 2018).
During the exposure period, three cMetS-S trajectory groups were identified: low, medium, and high (28.3, 50.0, and 21.7 percent, respectively). The researchers found that after adjustment for age, sex, education, smoking, physical activity, baseline estimated glomerular filtration rate, and even after further adjustment for MetS components, a high cMetS-S trajectory pattern was associated with an increased risk for CKD (hazard ratio, 1.32). Even in normoglycemic, nonobese, and nonhypertensive individuals, the associated risk remained significant. The MetS severity score was associated with CKD only in men in a sex-specific subgroup analysis.
"Physicians can monitor metabolic health changes by including the MetS score in routine lab results, allowing for improved metabolic health management through self-awareness and health behavior adjustments at no extra expense," the authors write. "Additional research is required to establish the risk thresholds for health results within the scoring framework."
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted August 2025
Read this next
Predialysis Nephrology Care Disparities Contribute to Vascular Access
FRIDAY, Sept. 5, 2025 -- System-based disparities in predialysis access to nephrology care contribute to disparities in the likelihood of having a mature, usable arteriovenous...
Mortality Rates From Hypertensive Renal Disease Increased From 1999 to 2023
FRIDAY, Sept. 5, 2025 -- From 1999 to 2023, there was an increase in age-adjusted mortality rates (AAMRs) for hypertensive renal disease, according to a study presented at the...
Novel Biomarker Risk Prediction Models Examined in Chronic Kidney Disease
FRIDAY, Aug. 22, 2025 -- For adults with nondialysis chronic kidney disease (CKD), risk prediction models incorporating novel biomarkers show comparable discrimination to...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.