Liso-Cel Cost-Effective for Second-Line Relapsed/Refractory Lymphoma
By Elana Gotkine HealthDay Reporter
THURSDAY, Jan. 4, 2024 -- Lisocabtagene maraleucel (liso-cel), a chimeric antigen receptor (CAR) T-cell therapy, is cost-effective for second-line diffuse large B-cell lymphoma (DLBCL) therapy, according to a study published online Dec. 28 in Blood Advances.
Jee H. Choe, from the University of Southern California in Los Angeles, and colleagues evaluated the cost-effectiveness of liso-cel versus platinum-based chemotherapy followed by autologous hematopoietic stem cell transplantation for relapsed and refractory DLBCL using a partitioned survival model with standard parametric functions over a lifetime horizon. The model employed a hypothetical cohort of DLBCL patients, aged 60 years (57 percent male), with refractory DLBCL or who relapsed early, within 12 months of initial treatment.
The researchers found that for the representative cohort, the incremental cost-effectiveness ratio of liso-cel was $99,669 per quality-adjusted life year (QALY) from a health care sector perspective and $68,212 per QALY from a societal perspective, confirming cost-effectiveness at the threshold of $100,000 per QALY. Liso-cel surpassed this benchmark under certain scenarios but remained within the acceptable range of $150,000 per QALY in the United States.
"Our study contributes novel insights to the expanding research on the economic and societal implications of CAR T-cell therapies," the authors write. "It reaffirms the importance of evaluating CAR T-cell therapies beyond their immediate costs, emphasizing their long-term clinical and societal impacts for a more comprehensive assessment of their overall value."
Several authors disclosed ties to the pharmaceutical industry.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted January 2024
Read this next
CD7 CAR T-Cell Therapy, Stem-Cell Transplant Beneficial for CD7-Positive Tumors
THURSDAY, April 25, 2024 -- For patients with relapsed or refractory CD7-positive leukemia or lymphoma, sequential CD7 chimeric antigen receptor (CAR) T-cell therapy followed by...
Second Primary Malignancy Risk Increased After Cutaneous B-Cell Lymphoma
WEDNESDAY, April 3, 2024 -- Patients with primary cutaneous B-cell lymphomas (PCBCLs) have an increased risk for second primary malignancies (SPMs), according to a study published...
Survival 21 Percent a Year After ICU Discharge for Blood Cancer Patients
THURSDAY, March 21, 2024 -- For hematologic malignancy (HM) patients admitted to the intensive care unit (ICU), survival is 49 percent at seven days and 21 percent at 12 months...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.