Lipoprotein(a) Levels Tied to Increased Risk of Recurrent Atherosclerotic CVD Events
By Elana Gotkine HealthDay Reporter
WEDNESDAY, May 21, 2025 -- Higher lipoprotein(a) levels are associated with continuously increasing risk of recurrent atherosclerotic cardiovascular disease (ASCVD) events, regardless of sex and race/ethnicity, according to a study published online May 7 in the European Heart Journal.
Noting that higher levels of lipoprotein(a) drive increasing risk of ASCVD in otherwise healthy individuals, Diane E. MacDougall, from the Family Heart Foundation in Fernandina Beach, Florida, and colleagues examined whether this is also true for recurrent ASCVD. Among U.S. medical claims between 2012 and 2022 for 340 million individuals, 273,770 had diagnosed ASCVD and lipoprotein(a) measures.
The researchers found that 15 percent of participants experienced recurrent ASCVD during a median follow-up of 5.4 years. There was an association for higher lipoprotein(a) levels with continuously increasing risk of recurrent ASCVD. For individual ASCVD components and in sex, race/ethnicity, baseline ASCVD, and diabetes subgroups, results were similar. The deleterious effect of lipoprotein(a) ≥180 nmol/L was possibly mitigated by high-impact low-density lipoprotein cholesterol (LDL)–lowering therapy, which was most pronounced for those on PCSK9 inhibitors (PCSK9i).
"Lipoprotein(a)-associated risk was similar regardless of baseline ASCVD and diabetes and may have been partially mitigated by the use of high-impact LDL cholesterol–lowering therapy, most pronounced in the case of PCSK9i use," the authors write.
Several authors disclosed ties to the biopharmaceutical industry.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted May 2025
Read this next
PREVENT Risk Score Accurately IDs People With Coronary Artery Calcium
WEDNESDAY, May 21, 2025 -- The 2023 Predicting Risk of Cardiovascular Disease Events (PREVENT) risk score accurately identifies individuals with coronary artery calcium (CAC)...
Intensive BP Reduction Effective for Lowering All-Cause Dementia Risk
TUESDAY, April 29, 2025 -- An intensive blood pressure (BP) reduction intervention is effective for lowering the risk for all-cause dementia among individuals aged 40 years and...
2005 to 2019 Saw Increase in Incidence of Cervical Artery Dissection
FRIDAY, April 4, 2025 -- Cervical artery dissection (CeAD) incidence increased from 2005 to 2019, with the increase in admissions particularly high in older, Black, and Hispanic...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.