Invasive Bladder Pressure Tests for Refractory Overactive Bladder May Be Avoided
By Elana Gotkine HealthDay Reporter
TUESDAY, April 1, 2025 -- Urodynamics plus comprehensive clinical assessment (CCA) is not superior to CCA only for women with refractory overactive bladder or urgency predominant mixed urinary incontinence, according to a study published in the March 29 issue of The Lancet to coincide with the 40th Annual European Association of Urology Congress, held from March 21 to 24 in Madrid.
Mohamed Abdel-Fattah, M.D., from the University of Aberdeen in the United Kingdom, and colleagues conducted a superiority trial in 63 U.K. hospitals to compare the clinical effectiveness and cost-effectiveness of urodynamics plus CCA versus CCA only in the management of women with refractory overactive bladder symptoms. Women aged 18 years or older with refractory overactive bladder or urgency predominant mixed urinary incontinence, with failed conservative management and being considered for invasive treatment, were randomly assigned to urodynamics plus CCA versus CCA only (550 and 549 patients, respectively).
The researchers found that the participant-reported success rates of "very much improved" or "much improved" were not superior in the urodynamics plus CCA group versus the CCA-only group at the final follow-up time point at 15 months after randomization. Low and similar serious adverse events were seen between the groups. Per quality-adjusted life year (QALY) gained, the incremental cost-effectiveness ratio was £42,643. At a willingness-to-pay threshold of £20,000 per QALY gained, the cost-effectiveness acceptability curve showed urodynamics had a 34 percent probability of being cost-effective, which reduced further when extrapolated over the patient's lifetime.
"Significantly more women who underwent CCA only report earlier improvement in their symptoms," the authors write.
Several authors disclosed ties to the biopharmaceutical industry.
Editorial (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted April 2025
Read this next
Urinary Incontinence Linked to CVD Risk Factors, Comorbid Conditions
FRIDAY, May 2, 2025 -- Urinary incontinence is not associated with moderate-to-vigorous physical activity (MVPA) classification, but is associated with cardiovascular disease...
MicroRNA-Based Germline Signature Predicts RT-Induced Genitourinary Toxicity in Prostate Cancer
FRIDAY, April 18, 2025 -- A biomarker consisting primarily of microRNA-based germline biomarkers (mirSNPs), PROSTOX, is valid for predicting radiotherapy (RT)-induced...
Geriatric Nutritional Risk Index Predictive for Overactive Bladder
MONDAY, April 7, 2025 -- The Geriatric Nutritional Risk Index (GNRI) is a reliable predictive marker for overactive bladder (OAB) in the elderly, according to a study published...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.