Intensive BP Control Linked to Long-Term Cognitive Benefits
By Elana Gotkine HealthDay Reporter
TUESDAY, Jan. 28, 2025 -- In an extended follow-up study, intensive blood pressure control is associated with reductions in the rate of cognitive impairment, according to a study published in the Feb. 11 issue of Neurology.
David M. Reboussin, Ph.D., from Wake Forest University School of Medicine in Winston-Salem, North Carolina, and colleagues conducted a prespecified analysis of a randomized clinical trial (the Systolic Blood Pressure Intervention Trial [SPRINT]) to estimate the effect of intensive versus standard systolic blood pressure (SBP) lowering on the longer-term incidence of cognitive impairment. Patients aged 50 years and older with hypertension and increased cardiovascular risk were recruited between 2010 and 2013 and were randomly assigned to an SBP goal of <120 or <140 mm Hg (intensive or standard treatment, respectively) and treated for 3.3 years.
Overall, 7,221 of the 9,361 randomized participants were eligible to be recontacted. The cognitive status of 4,232 participants was ascertained. The researchers found that during a median follow-up of seven years, 248 and 293 participants in the intensive and standard treatment groups were adjudicated with probable dementia (8.5 versus 10.2 per 1,000 person-years; hazard ratio, 0.86; 95 percent confidence interval [CI], 0.72 to 1.02). The rates of both mild cognitive impairment (MCI) and a composite of MCI or probable dementia were lower with intensive treatment, consistent with earlier results from the trial (hazard ratios, 0.87 [95 percent CI, 0.76 to 1.00] and 0.89 [95 percent CI, 0.79 to 0.99], respectively).
"Over a median of almost seven years of follow-up, we observed that the previously reported statistically significant reduction in the rate of cognitive impairment (composite of MCI or probable dementia) was maintained," the authors write.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted January 2025
Read this next
Salt Substitutes Infrequently Used by U.S. Adults
FRIDAY, Sept. 5, 2025 -- Few U.S. adults use salt substitutes (SS), including those with hypertension, according to a study presented at the American Heart Association...
Mortality Rates From Hypertensive Renal Disease Increased From 1999 to 2023
FRIDAY, Sept. 5, 2025 -- From 1999 to 2023, there was an increase in age-adjusted mortality rates (AAMRs) for hypertensive renal disease, according to a study presented at the...
Sense of Life Purpose Lowers Risk for Cognitive Impairment
THURSDAY, Sept. 4, 2025 -- A sense of purpose in life (PiL) is associated with a lower risk for and later onset of cognitive impairment, according to a study published online in...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.