High Insulin Levels Genetically Linked to Lower Lipoprotein(a)
By Lori Solomon HealthDay Reporter
WEDNESDAY, Sept. 4, 2024 -- There is an association between genetically predicted increased insulin concentrations and decreased concentrations of circulating lipoprotein(a) (Lp[a]), according to a study published online Aug. 29 in Cardiovascular Diabetology to coincide with the European Society of Cardiology Congress 2024, held from Aug. 30 to Sept. 2 in London.
Mateusz Lejawa, from the University of Silesia in Katowice, Poland, and colleagues examined the relationship between genetically predicted insulin concentrations and Lp(a) levels. The analysis included genetic variants strongly associated with fasting insulin levels from meta-analyses of genome-wide association studies in European populations (151,013 individuals) and summary-level data for Lp(a) from 361,194 participants in the U.K. Biobank.
The researchers found that genetically predicted fasting insulin levels were negatively associated with Lp(a) levels (β = −0.15). A sensitivity analysis supported a causal relationship between genetically predisposed insulin levels and Lp(a) using the weighted median method (β = −0.26), but not the Mendelian randomization-Egger method (β = −0.22).
"These findings suggest that hyperinsulinemia, which typically accompanies type 2 diabetes, can partially explain the inverse relationship between low Lp(a) concentrations and an increased risk of type 2 diabetes," the authors write. "Further studies are needed to validate and establish the exact mechanism behind this relationship."
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted September 2024
Read this next
Real-World Weight Loss With Semaglutide, Tirzepatide Less Than That Seen in Clinical Trials
THURSDAY, June 12, 2025 -- For patients with obesity initiating pharmacotherapy with semaglutide or tirzepatide, weight loss at one year is 8.7 percent on average, which is lower...
Increasing Proportion of U.S. Adults Unaware They Have Hypertension
MONDAY, June 9, 2025 -- From 2013 to 2023, there was an increase in the proportion of U.S. adults who were unaware of having hypertension, according to a research letter published...
Finerenone + Empagliflozin Offers Greater Benefit in CKD, T2DM
MONDAY, June 9, 2025 -- For patients with chronic kidney disease and type 2 diabetes, combination finerenone plus empagliflozin leads to a greater reduction in the urinary...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.