Hyperinsulinemia Linked to Abnormal Uterine Bleeding
By Elana Gotkine HealthDay Reporter
TUESDAY, June 10, 2025 -- In premenopausal women, hyperinsulinemia is associated with abnormal uterine bleeding (AUB), with body mass index (BMI) playing a role in this association, according to a study published online June 3 in Menopause.
Andrea C. Salcedo, D.O., M.P.H., from Loma Linda University School of Medicine in California, and colleagues conducted a cross-sectional study from June 2019 to August 2023 at a single institution's outpatient gynecology clinic involving 205 premenopausal women aged 18 to 54 years: 116 with AUB and 89 with normal menstrual cycles. Participants underwent fasting insulin assessment, with additional markers of metabolic syndrome. The association between hyperinsulinemia and AUB was examined, adjusting for confounders.
The researchers found that hyperinsulinemia significantly predicted AUB (odds ratio, 3.009). The significance of hyperinsulinemia was attenuated with inclusion of BMI in the model, suggesting overlapping or mediating pathways. Seventy-three percent concordance and improved model fit was achieved with the final model, which included age, low-density lipoprotein, and waist-to-hip ratio.
"These preliminary findings highlight the need for larger, longitudinal studies to confirm these relationships, identify causal mechanisms, and evaluate the potential of addressing hyperinsulinemia, being overweight, and obesity as part of prevention and treatment strategies for abnormal uterine bleeding," Stephanie Faubion, M.D., medical director of The Menopause Society, said in a statement.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.
Posted June 2025
Read this next
Similar Reduction Seen in Mortality for Exercise Patterns in Diabetes
TUESDAY, July 22, 2025 -- For patients with self-reported diabetes, weekend warrior and regular activity patterns meeting current physical activity recommendations are associated...
Prevalence of Extremely Severe Obesity Increasing in Children
TUESDAY, July 22, 2025 -- From 2008 to 2023, there was an increase in the prevalence of extremely severe obesity in children, especially among older adolescents and non-Hispanic...
Long-Term Obesity Linked to Expression of Aging Biomarkers
THURSDAY, July 17, 2025 -- Long-term obesity is associated with the expression of biomarkers denoting antagonistic and integrative aging hallmarks in adults aged 28 to 31 years...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.