HbA1c Stability Tied to Lower Risk for Alzheimer Disease and Related Dementias
By Lori Solomon HealthDay Reporter
THURSDAY, Aug. 8, 2024 -- Increased glycated hemoglobin (HbA1c) stability within patient-specific target ranges is associated with a lower risk for Alzheimer disease and related dementias (ADRD), according to a study published online Aug. 2 in JAMA Network Open.
Patricia C. Underwood, Ph.D., from the William F. Connell School of Nursing at Boston College, and colleagues examined the association between HbA1c time in range (TIR) and the incidence of ADRD in older veterans with diabetes. The analysis included 374,021 veterans with diabetes identified from administrative health care data (2005 to 2014) and followed for up to 10 years.
The researchers found that lower HbA1c TIR was associated with an increased risk for incident ADRD (HbA1c TIR of 0 to <20 percent versus ≥80 percent: hazard ratio, 1.193). The direction of out-of-range HbA1c levels was also associated with incident ADRD. Having greater time below range was associated with a significantly increased risk (hazard ratio, 1.23). When excluding individuals with baseline use of medications associated with hypoglycemia risk (e.g., insulin and sulfonylureas) or hypoglycemia events, findings remained significant.
"These results affirm the benefits of applying personalized HbA1c target ranges based on age, life expectancy, and comorbidities," the authors write. "Clinicians should work with patients to ensure HbA1c stability to reduce ADRD risk in older adults with diabetes."
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted August 2024
Read this next
GLP-1 Receptor Agonists Tied to Decrease in T2DM-Related Dementia Risk
WEDNESDAY, July 23, 2025 -- Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) are associated with reduced type 2 diabetes mellitus (T2DM)-related dementia risk compared with...
Endocrine Society, July 12-15
The annual meeting of the Endocrine Society (ENDO 2025) was held from July 12 to 15 in San Francisco, attracting more than 7,000 participants, including clinicians, academicians...
Similar Reduction Seen in Mortality for Exercise Patterns in Diabetes
TUESDAY, July 22, 2025 -- For patients with self-reported diabetes, weekend warrior and regular activity patterns meeting current physical activity recommendations are associated...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.