Glucarpidase Improves Outcomes in Patients With Methotrexate-Induced Kidney Toxicity
By Elana Gotkine HealthDay Reporter
THURSDAY, Jan. 16, 2025 -- For patients with methotrexate (MTX)-acute kidney injury (AKI), glucarpidase is associated with improved renal and extrarenal outcomes, according to a study published online Jan. 6 in Blood.
Shruti Gupta, M.D., M.P.H., from Brigham and Women's Hospital in Boston, and colleagues examined the association between glucarpidase administration and outcomes among adults with MTX-AKI from 28 cancer centers across the United States. Outcomes were compared for patients who received glucarpidase within four days following MTX initiation and those who did not; data were included for 708 patients with MTX-AKI, 209 (29.5 percent) of whom received glucarpidase.
The researchers found that 25.8 percent of patients had a primary end point event (kidney recovery at hospital discharge). Compared with no glucarpidase receipt, receipt was associated with 2.70-fold increased odds of kidney recovery. In addition, patients receiving glucarpidase had faster time to kidney recovery (adjusted hazard ratio, 1.88) and lower risks for grade ≥2 neutropenia and grade ≥2 transaminitis on day 7 (adjusted odds ratios, 0.50 and 0.50, respectively). No difference was seen between the groups in time to death.
"We found that patients with MTX-AKI treated with glucarpidase had a higher adjusted odds of kidney recovery compared to those not treated with glucarpidase," the authors write. "Randomized clinical trials are needed to confirm our findings, and also to explore the efficacy of glucarpidase in patients with plasma MTX levels that do not meet thresholds suggested by current guidelines."
Several authors disclosed ties to biopharmaceutical and health care companies, including BTG International, which funded the study.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted January 2025
Read this next
Biomarker Panel Improves Prediction of CKD Progression in Children
TUESDAY, June 24, 2025 -- A biomarker panel can improve prediction of chronic kidney disease (CKD) progression in children, according to a study published in the June issue of the...
Worse Outcomes Seen for Unvaccinated Patients Hospitalized With COVID-19, AKI
WEDNESDAY, June 18, 2025 -- For patients hospitalized with COVID-19 infection and acute kidney injury (AKI), those who are unvaccinated have worse outcomes in terms of kidney...
Electronic Nudge Letters Do Not Improve Guideline-Directed Medical Therapy in CKD
TUESDAY, June 17, 2025 -- Neither delivery of electronic nudge letters nor letters to general practice increase uptake of guideline-directed medical therapy (GDMT) among patients...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.