Skip to main content

Glucarpidase Improves Outcomes in Patients With Methotrexate-Induced Kidney Toxicity

By Elana Gotkine HealthDay Reporter

Medically reviewed by Carmen Pope, BPharm. Last updated on Jan 16, 2025.

via HealthDay

THURSDAY, Jan. 16, 2025 -- For patients with methotrexate (MTX)-acute kidney injury (AKI), glucarpidase is associated with improved renal and extrarenal outcomes, according to a study published online Jan. 6 in Blood.

Shruti Gupta, M.D., M.P.H., from Brigham and Women's Hospital in Boston, and colleagues examined the association between glucarpidase administration and outcomes among adults with MTX-AKI from 28 cancer centers across the United States. Outcomes were compared for patients who received glucarpidase within four days following MTX initiation and those who did not; data were included for 708 patients with MTX-AKI, 209 (29.5 percent) of whom received glucarpidase.

The researchers found that 25.8 percent of patients had a primary end point event (kidney recovery at hospital discharge). Compared with no glucarpidase receipt, receipt was associated with 2.70-fold increased odds of kidney recovery. In addition, patients receiving glucarpidase had faster time to kidney recovery (adjusted hazard ratio, 1.88) and lower risks for grade ≥2 neutropenia and grade ≥2 transaminitis on day 7 (adjusted odds ratios, 0.50 and 0.50, respectively). No difference was seen between the groups in time to death.

"We found that patients with MTX-AKI treated with glucarpidase had a higher adjusted odds of kidney recovery compared to those not treated with glucarpidase," the authors write. "Randomized clinical trials are needed to confirm our findings, and also to explore the efficacy of glucarpidase in patients with plasma MTX levels that do not meet thresholds suggested by current guidelines."

Several authors disclosed ties to biopharmaceutical and health care companies, including BTG International, which funded the study.

Abstract/Full Text (subscription or payment may be required)

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.

Read this next

Suboptimal Dialysis Initiation Common in Patients With Advanced CKD

FRIDAY, July 25, 2025 -- Suboptimal dialysis initiation, typically defined as dialysis initiation during a hospitalization and/or with a central venous catheter, is common among...

Standardization Needed for Dialysis Initiation in Pregnancy

WEDNESDAY, July 23, 2025 -- The initiation of dialysis in women with chronic kidney disease during pregnancy varies by clinical practice, signaling a need for standardized care in...

Atopic Dermatitis May Be Linked to Increased Risk for CKD

TUESDAY, July 15, 2025 -- Atopic dermatitis (AD) was associated with an increased risk for chronic kidney disease (CKD) in an Asian population, according to a study published...

More news resources

Subscribe to our newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.