Endovascular Therapy Improves Left Ventricular Diastolic Function in HFpEF
By Elana Gotkine HealthDay Reporter
FRIDAY, Sept. 20, 2024 -- For patients with heart failure with preserved ejection fraction (HFpEF), endovascular treatment (EVT) improves left ventricular (LV) diastolic function, according to a study published online Sept. 9 in Circulation: Heart Failure.
Sven Baasen, M.D., from the University Düsseldorf in Germany, and colleagues examined whether EVT of flow-limiting peripheral stenosis improved LV diastolic function among 30 patients with symptomatic peripheral artery disease and HFpEF who were scheduled for EVT or angiography. Patients were examined at baseline, the day after EVT or angiography (25 and five individuals, respectively), and at four-month follow-up.
The researchers observed a significant change in peripheral hemodynamics after EVT, with a decrease in total peripheral resistance and an increase in common femoral artery flow and ankle brachial index. After EVT, there was an improvement in aortic function, with a significantly reduced augmentation index and pulse wave velocity and increased compliance, resulting in a decline in aortic pulsatile load. Compared with control, LV diastolic function improved after EVT, acutely and at follow-up, with increased septal and lateral e' velocities and decreased E/e' and left atrial volume index. At follow-up, there were decreases in LV mass index and LV mean wall thickness. Post-EVT, there was improvement in the New York Heart Association class and treadmill walking distance at follow-up. Independent contributors to E/e' included augmentation index, pulse wave velocity, and arterial compliance.
"Successful endovascular treatment of flow-limiting stenosis in patients with definite HFpEF acutely led to improvement of diastolic function, with a sustained effect at the four-month follow-up," the authors write.
Editorial (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted September 2024
Read this next
Seniors With RSV-Linked Hospitalization Have Increased Cardiovascular Outcomes
THURSDAY, July 24, 2025 -- In older adults, respiratory syncytial virus (RSV) is associated with an increased risk for cardiovascular outcome, especially heart failure events...
Wildfire Smoke Exposure Increases Risk for Heart Failure
TUESDAY, July 8, 2025 -- Wildfire smoke exposure over time may increase the risk for heart failure, according to a study published in the July issue of the Journal of the...
A-Fib Catheter Ablation Cuts Risk for Ischemic Stroke After 30 Days, Mortality, Heart Failure Hospitalization
MONDAY, July 7, 2025 -- For patients with atrial fibrillation, catheter ablation reduces the risks for ischemic stroke at more than 30 days, mortality, and heart failure...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.