Endoscopic Sinus Surgery Beneficial for Chronic Rhinosinusitis
THURSDAY, Sept. 4, 2025 -- For patients with chronic rhinosinusitis, endoscopic sinus surgery improves disease-specific quality of life at six months, according to a study published online Aug. 30 in The Lancet.
Carl Philpott, M.D., from the University of East Anglia in the United Kingdom, and colleagues conducted a pragmatic, three-arm placebo-controlled, phase 4 trial to compare the clinical effectiveness of endoscopic sinus surgery or three months of clarithromycin treatment alongside intranasal medication in adults with chronic rhinosinusitis with or without nasal polyps. A total of 410 adults with chronic rhinosinusitis with nasal polyps and 104 with chronic rhinosinusitis without nasal polyps were recruited and randomly assigned to receive endoscopic sinus surgery, clarithromycin (250 mg twice daily for two weeks followed by 250 mg once daily for 10 weeks), or placebo, all with intranasal medication (171, 172, and 171, respectively). The primary outcome measure was the total score on the 22-item Sino-Nasal Outcome Test (SNOT-22) quality-of-life questionnaire at six months after randomization.
The researchers found that at six months after randomization, SNOT-22 scores were significantly lower in the endoscopic surgery group versus the clarithromycin group and placebo group (adjusted mean difference, –18.13 and –20.44, respectively). No significant difference was seen in six-month SNOT-22 scores for those randomly assigned to clarithromycin or placebo.
"What we found is that surgery was effective at reducing symptoms six months on, while taking the course of antibiotics seemed to make little difference," Philpott said in a statement. "Until now, there was no evidence in the form of a trial that showed sinus surgery works better than medical treatment, and access to sinus surgery has been restricted in some parts of the U.K. in recent years. This could be a real game-changer for sufferers worldwide."
Several authors disclosed ties to the pharmaceutical and medical device industries.
Editorial (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Read this next
Metabolic Surgery Has Greater Long-Term Benefits Than GLP-1 Receptor Agonists
WEDNESDAY, Oct. 1, 2025 -- People with obesity and type 2 diabetes who undergo metabolic surgery live longer and face fewer serious health problems compared with patients treated...
Adenotonsillectomy May Be No Better Than Watchful Waiting in Young Children With Mild OSA
TUESDAY, Sept. 30, 2025 -- For young children with mild obstructive sleep apnea (OSA) and small tonsils, adenotonsillectomy (ATE) seems to be no more effective than watchful...
Remote Perioperative Telemonitoring Beneficial After Cancer Surgery
THURSDAY, Sept. 25, 2025 -- Remote perioperative telemonitoring (RPM) improves postoperative functional recovery and symptoms among patients undergoing surgery for cancer...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.