Dose-Dependent Link Seen for Alcohol, Cirrhosis, Liver Cancer in Patients With Hep B
WEDNESDAY, Jan. 29, 2025 -- For patients with hepatitis B virus, alcohol is associated with dose-dependent increased risks for cirrhosis and hepatocellular carcinoma (HCC), according to a review published online Jan. 21 in the Journal of Clinical and Translational Hepatology.
Yin-Ping Wu, from the Qilu University Hospital of Shandong University in Jinan, China, and colleagues pooled data on the incidence of cirrhosis and HCC and developed a dose-dependent model of the effect of alcohol on cirrhosis and HCC. Data were included for 33,272 patients with hepatitis B virus from 45 studies.
The researchers found that the overall pooled odds ratios were 2.27 and 2.61 for cirrhosis and HCC, respectively, among drinkers versus nondrinkers. Compared with low-level drinkers, high-level drinkers had estimated pooled odds ratios of 2.34 and 2.42 for cirrhosis and HCC, respectively. A linear dose-dependent analysis showed that each daily consumption of 12 g of alcohol increased the risks for cirrhosis and HCC by 6.2 and 11.5 percent, respectively.
"Our meta-analysis is the first report to show that alcohol consumption increases the risk of cirrhosis and HCC in patients with HBV infection in a dose-dependent manner," the authors write.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Read this next
Parental Diseases of Despair Linked to Suicidal Events in Offspring
MONDAY, Sept. 15, 2025 -- Parental diseases of despair (DoD; i.e., substance use disorder, alcohol-related disease, or suicidal behavior) are associated with suicidal events (SE)...
Hepatitis B Virus Immunity Linked to Reduced Risk for Diabetes
THURSDAY, Sept. 11, 2025 -- Hepatitis B virus (HBV) immunity in individuals without HBV infection is associated with a reduced risk for diabetes, according to a study published...
Healthy Eating, Physical Activity Reduce Risk for Alcohol-Related Liver Mortality
TUESDAY, Sept. 2, 2025 -- Healthy eating and increased levels of physical activity (PA) significantly lower the risk for alcohol-attributable liver-related mortality, according to...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.