Skip to main content

Dementia Diagnoses Up in Individuals With Acute Kidney Injury

By Elana Gotkine HealthDay Reporter

Medically reviewed by Carmen Pope, BPharm. Last updated on Sep 5, 2024.

via HealthDay

THURSDAY, Sept. 5, 2024 -- Individuals with acute kidney injury (AKI) have an increased risk for receiving a clinical diagnosis of dementia, according to a study published online Aug. 22 in Neurology.

Hong Xu, M.D., Ph.D., from the Karolinska Institutet in Stockholm, and colleagues examined the association between experiencing AKI and subsequent risks for developing dementia in a study involving individuals aged 65 years and older in Stockholm, who were free from dementia diagnosis. A total of 305,122 individuals (median age, 75 ± 8 years) were included.

The researchers found that 79,888 individuals (26 percent) were suffering from a least one episode of AKI during a median follow-up of 12.3 years and there were 47,938 (16 percent) incident dementia cases. The rate of dementia cases was 37.0 per 1,000 person-years after AKI compared with 17.3 during the period before AKI. Developing AKI was associated with a significantly increased rate of subsequent dementia after multivariable adjustment (adjusted hazard ratio, 1.49). Across dementia types, this pattern was consistent, with hazard ratios of 1.88, 1.47, and 1.31 for dementia with Lewy bodies and Parkinson disease with dementia, vascular dementia, and Alzheimer dementia, respectively. Across more severe AKIs and in hospital-acquired versus community-acquired AKI, risk associations were stronger in magnitude.

"As a clinical application, this study thus identifies individuals with AKI as a population in which monitoring for dementia and potential preventive and therapeutic strategies may be indicated," the authors write.

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.

Read this next

Risk for Dementia, Ischemic Stroke, Mortality Lower With GLP-1 Receptor Agonists in T2D, Obesity

TUESDAY, July 22, 2025 -- For adults with type 2 diabetes and obesity, glucagon-like peptide 1 receptor agonists (GLP-1 RAs) are associated with a lower risk for dementia, stroke...

Dementia Risk Does Not Differ With GLP-1 RAs, DPP4is for Seniors With T2DM

MONDAY, July 21, 2025 -- For older adults with diabetes, there is no clear evidence to suggest that the incidence of dementia differs for those using glucagon-like peptide 1...

Atopic Dermatitis May Be Linked to Increased Risk for CKD

TUESDAY, July 15, 2025 -- Atopic dermatitis (AD) was associated with an increased risk for chronic kidney disease (CKD) in an Asian population, according to a study published...

More news resources

Subscribe to our newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.