Cognitive Impairment, Work Productivity Loss Linked in Bipolar Disorder
By Elana Gotkine HealthDay Reporter
MONDAY, Aug. 18, 2025 -- There is a weak correlation between change in cognitive impairment and change in work productivity loss in adults with bipolar disorder, according to a study published online Aug. 4 in the Neuropsychopharmacology Reports.
Yoshikazu Takaesu, M.D., Ph.D., from the University of the Ryukyus in Okinawa, Japan, and colleagues conducted a prospective 48-week longitudinal, web-based, cohort questionnaire study involving adults with bipolar disorder in Japan who were employed or on sick leave. From baseline to week 48, validated self-administered rating scales assessing cognitive impairment, work productivity loss, quality of life (QOL), depressive symptom severity, and sleep disturbance were completed every 12 weeks. The correlation between change from baseline at 48 weeks in cognitive impairment and work productivity loss was the primary end point.
One hundred seventy-nine participants responded to all the study questionnaires and were included in this 48-week analysis. The researchers identified a weak correlation between change in cognitive impairment and change in work productivity loss (presenteeism) from baseline to week 48, but no association was seen on the multiple regression analysis. There was a significant association seen between change in work productivity loss and change in depressive symptoms. A significant association was seen between change in QOL with change in insomnia.
"This 48-week longitudinal analysis showed that there was a weak correlation between change from baseline at 48 weeks in cognitive impairment and work productivity loss," the authors write. "However, change in depressive symptoms (core symptoms of bipolar disorder) was associated with change in work productivity loss."
Several authors disclosed ties to pharmaceutical companies, including Sumitomo Pharma Co., which funded the study.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted August 2025
Read this next
COVID-19 Infection Linked to Accelerated Vascular Aging
MONDAY, Aug. 18, 2025 -- COVID-19 is associated with early vascular aging, as assessed by carotid-femoral pulse wave velocity (PWV), an established biomarker of large artery...
Rate of Sexual Dysfunction Similar in Middle-Aged, Older Women
MONDAY, Aug. 18, 2025 -- Older women experience female sexual dysfunction (FSD) at similar rates as midlife women but report less sexual distress, according to a study published...
Parents' Occupational Exposure Tied to Offspring's Autism Severity
MONDAY, Aug. 18, 2025 -- Several classes of parental occupational exposures are associated with autism spectrum disorder (ASD) severity and several behavioral subscales, according...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.