Children With Primary Ciliary Dyskinesia Likely to Have Asthma
By Elana Gotkine HealthDay Reporter
FRIDAY, Dec. 20, 2024 -- Most children with likely primary ciliary dyskinesia (PCD) have asthma, according to a research letter published online Dec. 9 in JAMA Network Open.
Joe Zein, M.D., Ph.D., from the Mayo Clinic in Scottsdale, Arizona, and colleagues conducted a case-control study to examine the association between PCD and asthma in children aged 18 years or younger. The combination of two diagnoses that are unlikely to occur together in the absence of PCD, specifically bronchiectasis and situs inversus totalis (B-SIT), was analyzed; individuals with B-SIT were then asked whether they also had a diagnosis of asthma. This study included 124 B-SIT patients and 142 controls matched for age, sex, ethnicity, and race: nine children with B-SIT and 27 controls from the Indiana Network for Patient Care Research (INPCR) cohort and 115 cases and 115 controls from the validation cohort, TriNetX.
The researchers found that in the INPCR cohort, all nine B-SIT children and one control had asthma. In the TriNetX cohort, 84 with B-SIT and 12 controls had asthma. The adjusted odds ratio was 22.3 for patients with B-SIT having asthma.
"In summary, children with PCD may need to be evaluated for asthma," the authors write. "Consideration should also be given to whether some children with asthma may have cardinal features of PCD."
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted December 2024
Read this next
Coal Coking Plant Closure Tied to Immediate and Long-Term Respiratory Health Benefits
WEDNESDAY, July 30, 2025 -- Reductions in fossil fuel-related air pollution are linked to both short- and long-term lung health benefits for nearby residents, according to a study...
Illness Expectations Tied to Asthma Outcomes
WEDNESDAY, July 16, 2025 -- Illness expectations may be meaningfully associated with asthma symptoms and respiratory function, according to a study published online in the June...
Moderate-to-Severe Asthma Up for Female Permanent Night Shift Workers
THURSDAY, June 26, 2025 -- Female permanent night shift workers have higher odds of moderate-to-severe asthma than female day workers, but this relationship is not seen in men...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.