Bladder Wall Thickness Reflects Severity of Bladder Inflammatory Conditions
By Elana Gotkine HealthDay Reporter
FRIDAY, March 7, 2025 -- For patients with interstitial cystitis/bladder pain syndrome (IC/BPS), bladder wall thickness (BWT) on computed tomography (CT) scans reflects the severity of bladder inflammatory conditions, according to a study published online Feb. 4 in the World Journal of Urology.
Wan-Ru Yu, from Hualien Tzu Chi Hospital in Taiwan, and colleagues analyzed BWT and compared bladder conditions, urinary biomarkers, and histopathology among patients with IC/BPS with different BWT. One hundred eighty-two patients with cystoscopy-proven IC/BPS underwent abdominal CT before intervention; BWT was classified as smooth, focal thickness, and diffuse thickness (85, 64, and 33 patients, respectively).
The researchers found that patients with focal and diffuse BWT were significantly older, with higher symptom scores, smaller bladder capacity, higher grade of glomerulations, and higher incidence of Hunner's IC. The greatest uroepithelial cell denudation and plasma cell infiltration was seen for patients with diffuse BWT, followed by those with focal thickness. Higher rates of inflammatory cell infiltration, nerve bundle hyperplasia, and granulation tissue were seen for patients with diffuse BWT. Compared with controls, patients with IC/BPS with different BWT had significantly higher urinary levels of tumor necrosis factor alpha and oxidative stress biomarkers.
"A bladder wall that shows focal or diffuse thickness indicates more severe inflammation and reduced maximal bladder capacity on cystoscopic hydrodistention," the authors write.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.
Posted March 2025
Read this next
Inflammation and Nutrition-Based Scores Tied to Prognosis of Low-Risk Myelodysplastic Syndrome
THURSDAY, July 24, 2025 -- The Prognostic Nutritional Index (PNI) and systemic oxidative stress (SOS) score are independently associated with poorer prognosis of low-risk...
Subclinical Synovitis Risk Higher in Psoriasis Without Musculoskeletal Involvement
TUESDAY, July 22, 2025 -- Subclinical synovitis is significantly more common among patients with psoriasis without musculoskeletal involvement than healthy controls, according to...
Childhood GI Disorders May Be Predictive for Interstitial Cystitis
TUESDAY, July 22, 2025 -- Childhood gastrointestinal (GI) disorders may be predictive for interstitial cystitis (IC), according to a study published online June 25 in Neurourology...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.