Anatomic Changes Can Be Seen With MRI-Linac for Glioblastoma Patients
By Elana Gotkine HealthDay Reporter
FRIDAY, Oct. 11, 2024 -- For patients with glioblastoma imaged daily with magnetic resonance imaging (MRI)-linear accelerator (linac) throughout the chemoradiation therapy course, anatomic changes can be detected, according to a study published online Sept. 30 in the International Journal of Radiology Oncology - Biology - Physics.
Kaylie Cullison, Ph.D., from the University of Miami Miller School of Medicine, and colleagues examined dynamics of daily glioblastoma evolution during chemoradiation therapy among 36 patients with glioblastoma. Tumor or edema (lesion) and resection cavity dynamics were analyzed throughout treatment on 0.35T MRI-linac and at three timepoints (T) with and without contrast (C) on standalone high-field MRI. Of the patients, eight, 12, and 16 had cavity only, lesions only, and cavity and lesions, respectively.
The researchers found that on MRI-linac scans, 64 and 46 percent of the patients had lesion growth and cavity shrinkage during treatment, respectively. The average MRI-linac migration distance was 1.3 and 0.6 cm for lesion and cavity, respectively. There was a strong correlation observed for standalone versus MRI-linac volumes (R2 values of 0.991, 0.972, and 0.973 for T2 versus MRI-linac cavity, T1 + C versus MRI-linac cavity, and T2 versus MRI-linac lesion), respectively. A moderate correlation was seen between T1 + C and MRI-linac lesions (R2, 0.609). In patients with all available scans, from pretreatment to posttreatment, T1 + C and MRI-linac lesions changed together in 74 percent of patients (shrank, grew, and did not change in six, 12, and eight, respectively). Nine patients (26 percent) had growth on MRI-linac and shrinkage on T1 + C.
"Our study shows that these daily scans can serve as an early warning sign for potential tumor growth," Cullison said in a statement.
Several authors disclosed ties to ViewRay.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted October 2024
Read this next
Diagnostic Model Based on Delayed Post-Gadolinium Enhancement MRI Accurate for Meniere Disease
TUESDAY, July 15, 2025 -- A diagnostic model based on delayed post-gadolinium enhancement magnetic resonance imaging (DEMRI) improves the accuracy of Meniere disease (MD)...
AI Support Improves Breast Cancer Detection Accuracy in Mammography
MONDAY, July 14, 2025 -- Artificial intelligence (AI) support improves radiologists' breast cancer detection accuracy when reading mammograms, according to a study published...
Presurgical Ablative Radiotherapy + Chemo Improves Pathologic Outcomes in Pancreatic Cancer
FRIDAY, July 11, 2025 -- Adding stereotactic ablative radiotherapy (SAbR) to neoadjuvant chemotherapy improves pathologic outcomes for patients diagnosed with pancreatic cancer...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.