Optical Coherence Tomography Feasible for Imaging Inner Ear
By Elana Gotkine HealthDay Reporter
WEDNESDAY, July 30, 2025 -- Imaging the inner ear during surgical procedures is feasible and allows detection of endolymphatic hydrops, according to a study published online July 23 in Science Translational Medicine.
Wihan Kim, from the University of Southern California, Los Angeles, and colleagues imaged the lateral and posterior semicircular canals of patients undergoing ear surgery and measured the endolymph-to-perilymph ratio by peering through the otic capsule bone during mastoid surgery, translating the technology of optical coherence tomography (OCT) for use in the human inner ear. The authors analyzed 19 patients in three cohorts: six with normal inner function (control group), four with Ménière disease, and nine with vestibular schwannoma.
The researchers found that compared with the control group, both patient groups demonstrated increased endolymph and reduced perilymph compared with normal controls, known as endolymphatic hydrops. For measuring the endolymph-to-perilymph ratio, good repeatability was seen with OCT imaging. The data indicated a correlation of increased endolymph-to-perilymph ratios with the degree of hearing loss. Small but meaningful changes in the inner ear fluid balance can be detected with this approach, the authors note, with resolution better than the current gold standard clinical imaging modality of gadolinium enhanced 3 Tesla magnetic resonance imaging.
"These findings are exciting because hearing loss can happen very suddenly, and we often don't know why. OCT offers a way to explore the underlying cause and potentially guide treatment," senior author John Oghalai, M.D., also from the University of Southern California, said in a statement.
Two authors are founders of AO technologies, which has a goal of translating inner ear imaging technologies for clinical purposes.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.
Posted July 2025
Read this next
Helping Others Linked to Higher Level of Cognitive Function
THURSDAY, Aug. 21, 2025 -- Helping others, both via formal volunteering and informal helping, is associated with higher levels of cognitive function and slower cognitive decline...
TAR-200 Monotherapy Promising for BCG-Unresponsive Bladder Cancer
THURSDAY, Aug. 21, 2025 -- For patients with Bacillus Calmette-Guérin (BCG)-unresponsive high-risk non-muscle-invasive bladder cancer (NMIBC), an intravesical...
Work-Related Income Drops for Parents of Children Diagnosed With Type 1 Diabetes
THURSDAY, Aug. 21, 2025 -- Work-related income decreases sharply for mothers and fathers of children diagnosed with type 1 diabetes, with similar effects across sociodemographic...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.