ACC: Bilateral Oophorectomy Linked to Increased Risk for Heart Failure
FRIDAY, March 28, 2025 -- Bilateral oophorectomy is associated with an increased risk for heart failure, with a greater risk seen with younger age and for White women, according to a study presented at the annual meeting of the American College of Cardiology, held from March 29 to 31 in Chicago.
Narathorn Kulthamrongsri, M.D., from the University of Hawaii in Honolulu, and colleagues conducted a cross-sectional analysis using data from the 2017 to 2020 National Health and Nutrition Examination Survey involving 3,972 women who reported their bilateral oophorectomy and heart failure status.
The mean age at oophorectomy onset was 43.6 ± 9.4 years and mean age for heart failure was 57 ± 16 years. The researchers found a 0.6-year delay in onset of heart failure in association with each one-year increase in oophorectomy age. Bilateral oophorectomy was associated with a 3.7-fold increase in the risk for heart failure, which remained significant after adjustment (odds ratio, 1.6). A stronger effect was seen in White women (odds ratios, 5.2 in univariate analysis and 2.7 in multivariate analysis).
"Women must do what is medically necessary in terms of oophorectomy, but our findings suggest they should have an informed discussion with their health care team about how to monitor their cardiovascular health and manage potential risk factors for heart failure, including adopting a healthy lifestyle as much as possible and perhaps asking about any potential role of hormone replacement therapy," Kulthamrongsri said in a statement.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
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