Skip to main content

ACC: Bilateral Oophorectomy Linked to Increased Risk for Heart Failure

By Elana Gotkine HealthDay Reporter

Medically reviewed by Carmen Pope, BPharm. Last updated on March 28, 2025.

via HealthDay

FRIDAY, March 28, 2025 -- Bilateral oophorectomy is associated with an increased risk for heart failure, with a greater risk seen with younger age and for White women, according to a study presented at the annual meeting of the American College of Cardiology, held from March 29 to 31 in Chicago.

Narathorn Kulthamrongsri, M.D., from the University of Hawaii in Honolulu, and colleagues conducted a cross-sectional analysis using data from the 2017 to 2020 National Health and Nutrition Examination Survey involving 3,972 women who reported their bilateral oophorectomy and heart failure status.

The mean age at oophorectomy onset was 43.6 ± 9.4 years and mean age for heart failure was 57 ± 16 years. The researchers found a 0.6-year delay in onset of heart failure in association with each one-year increase in oophorectomy age. Bilateral oophorectomy was associated with a 3.7-fold increase in the risk for heart failure, which remained significant after adjustment (odds ratio, 1.6). A stronger effect was seen in White women (odds ratios, 5.2 in univariate analysis and 2.7 in multivariate analysis).

"Women must do what is medically necessary in terms of oophorectomy, but our findings suggest they should have an informed discussion with their health care team about how to monitor their cardiovascular health and manage potential risk factors for heart failure, including adopting a healthy lifestyle as much as possible and perhaps asking about any potential role of hormone replacement therapy," Kulthamrongsri said in a statement.

Press Release

More Information

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.

Read this next

Urinary Metal Levels Tied to Increased Risk for Later Heart Failure

THURSDAY, July 3, 2025 -- There are consistent associations between elevated urinary metal levels and increased heart failure risk over time across geographically diverse cohorts...

Empagliflozin Has Kidney Protective Effects in Acute Myocardial Infarction

THURSDAY, June 26, 2025 -- Empagliflozin has kidney protective effects and reduces heart failure outcomes across baseline kidney function among patients with acute myocardial...

Quality Improvement Initiative Ups Adherence to Medical Therapy for Heart Failure

MONDAY, June 23, 2025 -- For patients with heart failure, hospital participation in the IMPLEMENT-HF initiative improves adherence to quadruple medication therapy (QMT), defined...

More news resources

Subscribe to our newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.