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Generic name: pramoxine and zinc acetate topicalpra-MOX-een-and-ZINK-as' e-tate-TOP-ik-al ]
Brand names: Calaclear, Caladryl Clear, Caldyphen Clear, Clear Anti Itch Lotion, Callergy Clear
Drug class: Topical anesthetics

Medically reviewed by on Aug 9, 2023. Written by Cerner Multum.

What is Calaclear?

Calaclear (for the skin) is a combination medicine used to relieve pain and itching caused by coming into contact with poison ivy, poison oak, or poison sumac. Calaclear also dries oozing or weeping from minor skin irritation.

Calaclear may also be used for purposes not listed in this medication guide.

Calaclear side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may be more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use Calaclear if you are allergic to it.

Ask a doctor before using Calaclear if you are pregnant or breastfeeding.

Do not use this medicine on a child younger than 2 years old without medical advice.

How should I use Calaclear?

Use exactly as directed on the label, or as prescribed by your doctor.

Do not take by mouth. Topical medicine is for use only on the skin.

Shake well before using.

Clean the affected area with soap and water and let it dry before each use. Apply Calaclear to the affected skin up to 3 to 4 times daily.

Stop using Calaclear and call your doctor if your symptoms do not improve within 7 days, if they get worse, or if they disappear and occur again within a few days.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

What happens if I overdose?

An overdose of Calaclear is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

What should I avoid while using pramoxine and zinc acetate topical?

Avoid getting Calaclear in your eyes or mucous membranes.

What other drugs will affect Calaclear?

Medicine used on the skin is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.