Generic Name: hyaluronidase (injectable) (HYE al ure ON i dase)
Brand Name: Amphadase, Hylenex, Vitrase
What is hyaluronidase?
Hyaluronidase is a genetically designed protein.
Hyaluronidase is used together with fluids injected into the body to treat dehydration. Hyaluronidase can also be used as an aid in helping your body absorb other injected medications.
Hyaluronidase is also used to help contrast dyes in your body show more clearly on certain types of x-rays or scans.
Hyaluronidase may also be used for purposes not listed in this medication guide.
What is the most important information I should know about hyaluronidase?
Serious drug interactions can occur when certain medicines are used together with hyaluronidase. Tell your doctor about all your current medicines.
What should I discuss with my health care provider before receiving hyaluronidase?
You should not be treated with hyaluronidase if you are allergic to it.
Your doctor may perform a skin test to see if you are allergic to hyaluronidase before you receive the medication.
Some medicines can cause unwanted or dangerous effects when used with hyaluronidase. Your doctor may need to change your treatment plan if you use any of the following drugs:
a sedative or anxiety medication (such as diazepam, lorazepam, alprazolam, Valium, Xanax, Ativan, Tranxene, and others);
aspirin or salicylates;
cortisone or ACTH (Corticotropin);
an antihistamine (such as a cold or allergy medicine).
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether hyaluronidase passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How is hyaluronidase given?
Hyaluronidase is injected under the skin, into a muscle, or into other tissues of the body.
A healthcare provider will give you this injection.
Hyaluronidase should not be injected into a vein (as an intravenous injection).
What happens if I miss a dose?
Because you will receive hyaluronidase in a clinical setting, you are not likely to miss a dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid after receiving hyaluronidase?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Hyaluronidase side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Common side effects may include:
pain, itching, or redness where the injection was given; or
swelling in your hands, feet, or body areas.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect hyaluronidase?
Other drugs may interact with hyaluronidase, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
More about Amphadase (hyaluronidase)
Related treatment guides
Where can I get more information?
- Your doctor or pharmacist can provide more information about hyaluronidase injection.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 5.01.
Last reviewed: March 30, 2016
Date modified: January 10, 2017