Generic Name: amphetamine and dextroamphetamine (am FET a meen and DEX troe am FET a meen)
Brand Name: Adderall, Adderall XR
What is amphetamine and dextroamphetamine?
Amphetamine and dextroamphetamine are central nervous system stimulants that affect chemicals in the brain and nerves that contribute to hyperactivity and impulse control.
Amphetamine and dextroamphetamine is a combination medicine used to treat narcolepsy and attention deficit hyperactivity disorder (ADHD).
Amphetamine and dextroamphetamine may also be used for purposes not listed in this medication guide.
What is the most important information I should know about amphetamine and dextroamphetamine?
You should not use this medicine if you have glaucoma, overactive thyroid, severe agitation, moderate to severe high blood pressure, heart disease or coronary artery disease, or a history of drug or alcohol addiction.
Do not use this medicine if you have taken an MAO inhibitor in the past 14 days, including isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Amphetamine and dextroamphetamine may be habit-forming. Never share this medicine with another person, especially someone with a history of drug abuse or addiction.
Using this medicine improperly can cause death or serious side effects on the heart.
What should I discuss with my healthcare provider before taking amphetamine and dextroamphetamine?
Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
You should not use amphetamine and dextroamphetamine if you are allergic to any stimulant medicine, or if you have:
moderate to severe high blood pressure;
heart disease or coronary artery disease (hardened arteries);
severe anxiety, tension, or agitation (stimulant medicine can make these symptoms worse); or
a history of drug or alcohol addiction.
Some stimulants have caused sudden death in certain people. Tell your doctor if you have:
heart problems or a congenital heart defect;
high blood pressure; or
a family history of heart disease or sudden death.
To make sure this medicine is safe for you, tell your doctor if you or anyone in your family has ever had:
depression, mental illness, bipolar disorder, psychosis, or suicidal thoughts or actions;
motor tics (muscle twitches) or Tourette's syndrome;
seizures or epilepsy;
an abnormal brain wave test (EEG); or
blood circulation problems in the hands or feet.
It is not known whether this medicine will harm an unborn baby. However, taking the medicine during pregnancy can cause premature birth, low birth weight, or withdrawal symptoms in the newborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Amphetamine and dextroamphetamine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using this medicine.
Amphetamine and dextroamphetamine is not approved for use by anyone younger than 6 years old.
How should I take amphetamine and dextroamphetamine?
Using this medicine improperly can cause death or serious side effects on the heart.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Amphetamine and dextroamphetamine may be habit-forming. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Selling or giving away this medicine is against the law.
You may take amphetamine and dextroamphetamine with or without food. It is best to take this medicine first thing in the morning.
Do not crush, chew, break, or open an extended-release capsule. Swallow it whole.
To make swallowing easier, you may open the capsule and sprinkle the medicine into a spoonful of applesauce. Swallow right away without chewing. Do not save the mixture for later use.
While using this medicine, your doctor will need to check your progress at regular visits. Your heart rate, blood pressure, height and weight may also need to be checked often.
Amphetamine and dextroamphetamine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using this medicine.
Store at room temperature away from moisture, heat, and light.
Keep track of the amount of medicine used from each new bottle. Amphetamine and dextroamphetamine is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.
What happens if I miss a dose?
Take the missed dose as soon as you remember, but not late in the day or you could have trouble sleeping. Skip the missed dose if it is almost evening. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of amphetamine and dextroamphetamine could be fatal.
Overdose symptoms may include restlessness, tremor, muscle twitches, rapid breathing, confusion, hallucinations, panic, aggressiveness, muscle pain or weakness, and dark colored urine. These symptoms may be followed by depression and tiredness. Other overdose symptoms include nausea, vomiting, diarrhea, stomach pain, uneven heartbeats, feeling light-headed, fainting, seizure (convulsions), or coma.
What should I avoid while taking amphetamine and dextroamphetamine?
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid drinking fruit juices or taking vitamin C at the same time you take amphetamine and dextroamphetamine. These can make your body absorb less of the medicine.
Amphetamine and dextroamphetamine side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Amphetamine and dextroamphetamine can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.
Stop using this medicine and call your doctor at once if you have:
chest pain, trouble breathing, feeling like you might pass out;
hallucinations (seeing or hearing things that are not real), new behavior problems, aggression, hostility, paranoia;
a seizure (convulsions);
numbness, pain, cold feeling, unexplained wounds, or skin color changes (pale, red, or blue appearance) in your fingers or toes;
muscle twitches (tics);
changes in your vision; or
unexplained muscle pain, tenderness, or weakness (especially if you also have fever, unusual tiredness, and dark colored urine).
Common side effects may include:
stomach pain, loss of appetite;
mood changes, feeling nervous;
fast heart rate;
sleep problems (insomnia); or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect amphetamine and dextroamphetamine?
Many drugs can interact with amphetamine and dextroamphetamine. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:
an antacid or other stomach acid reducer, such as Nexium, Pepcid, Prilosec, Protonix, Zantac, and others;
blood pressure medication;
a blood thinner such as warfarin (Coumadin, Jantoven);
a cold or allergy medicine that contains a decongestant such as pseudoephedrine or phenylephrine;
medicine to treat mental illness;
narcotic pain medicine; or
This list is not complete and many other drugs can interact with amphetamine and dextroamphetamine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
More about Adderall (amphetamine / dextroamphetamine)
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about amphetamine and dextroamphetamine.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 10.02.
Last reviewed: November 19, 2015
Date modified: November 30, 2016