Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- dinoprostone topical
- Pitocin (oxytocin)
Interactions between your drugs
oxytocin dinoprostone topical
Applies to: Pitocin (oxytocin), dinoprostone topical
ADJUST DOSING INTERVAL: Prostaglandins, especially those of the E type, may potentiate the uterine response to oxytocin and increase the risk of uterine hyperstimulation and rupture. The mechanism of interaction is unknown.
MANAGEMENT: Concomitant use of oxytocin and dinoprostone is considered to be contraindicated. Infusion of oxytocin should not be started until at least 6 to 12 hours after the use of dinoprostone vaginal gel (6 to 12 hours recommended for Prepidil Gel and 12 to 24 hours for Prostin E2 Vaginal Gel) or at least 30 minutes after the removal of dinoprostone vaginal insert, or at least 1 hour after the last dose of dinoprostone oral tablet.
References (3)
- (2001) "Product Information. Prepidil (dinoprostone topical)." Pharmacia and Upjohn
- (2002) "Product Information. Prostin E2 (dinoprostone topical)." Pharmacia and Upjohn
- (2002) "Product Information. Cervidil (dinoprostone topical)." Forest Pharmaceuticals
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
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Prostin E2
Prostin E2 is used for abortion, labor induction, trophoblastic disease
Learn more
Further information
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