Drug Interaction Report

ADJUST DOSING INTERVAL: Aluminum and magnesium containing antacids have been reported to decrease the bioavailability of delavirdine by an average of 41%. The mechanism may be related to decreased absorption of delavirdine. Other antacids may also interact.

MANAGEMENT: Delavirdine administration should be separated by at least 1 hour from one of these preparations.

ADJUST DOSING INTERVAL: Bowel cleansing products can increase the gastrointestinal transit rate. Oral medications administered within one hour of the start of administration of the bowel cleansing solution may be flushed from the gastrointestinal tract and not properly absorbed.

MANAGEMENT: Patients should be advised that absorption of oral medications may be impaired during bowel cleansing treatment. Oral medications (e.g., anticonvulsants, oral contraceptives, antidiabetic agents, antibiotics) should not be administered during and within one hour of starting bowel cleansing treatment whenever possible. However, if concomitant use cannot be avoided, monitoring for reduced therapeutic effects may be advisable.