Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Vitamin B12 (cyanocobalamin)
- Xermelo (telotristat)
Interactions between your drugs
No drug ⬌ drug interactions were found between the drugs in your list. However, this does not necessarily mean no drug interactions exist. Always consult your healthcare provider.
Drug and food interactions
telotristat ethyl food
Applies to: Xermelo (telotristat)
ADJUST DOSING INTERVAL: Food increases the systemic exposure to both telotristat ethyl and its active metabolite, telotristat. Following administration of a single 500 mg dose of telotristat ethyl (twice the recommended dose) with a high-fat meal, telotristat ethyl peak plasma concentration (Cmax) and systemic exposure (AUC) were 112% and 264% higher, respectively, compared to administration under fasted conditions. The Cmax and AUC values for telotristat were also increased by 47% and 33%, respectively. The in vitro inhibitory potency of telotristat towards tryptophan hydroxylase has been shown to be approximately 29 times higher than that of the parent drug.
MANAGEMENT: Telotristat ethyl should be administered with food.
References (1)
- (2017) "Product Information. Xermelo (telotristat ethyl)." Lexicon Pharmaceuticals, Inc.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Cyanokit
Cyanokit is used in an emergency to treat cyanide poisoning. Learn about side effects, interactions ...
Neuroforte-R
Neuroforte-R is used for B12 Nutritional Deficiency, pernicious anemia, schilling test, vitamin b12 ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Nascobal
Nascobal is used for B12 Nutritional Deficiency, pernicious anemia, schilling test, vitamin b12 ...
Hydroxocobalamin
Hydroxocobalamin is used for cyanide poisoning, schilling test, transcobalamin ii deficiency ...
Learn more
Further information
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